Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers beta-L-LNA and alpha-D-LNA; studies in the mirror image world

Two LNA (locked nucleic acid) stereoisomers (beta-L-LNA and alpha-D-LNA) are evaluated in the mirror-image world, that is by the study of two mixed sequences of LNA and alpha-L-LNA and their L-DNA and L-RNA complements. Both are found to display high-affinity RNA-recognition by the formation of dupl...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2004-02 (3), p.282-283
Main Authors: Christensen, Nanna K, Bryld, Torsten, Sørensen, Mads D, Arar, Khalil, Wengel, Jesper, Nielsen, Poul
Format: Article
Language:English
Subjects:
Base Sequence
Circular Dichroism
Nucleic Acid Conformation
Oligonucleotides
Oligonucleotides, Antisense - chemistry
RNA - chemistry
Stereoisomerism
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Summary:Two LNA (locked nucleic acid) stereoisomers (beta-L-LNA and alpha-D-LNA) are evaluated in the mirror-image world, that is by the study of two mixed sequences of LNA and alpha-L-LNA and their L-DNA and L-RNA complements. Both are found to display high-affinity RNA-recognition by the formation of duplexes with parallel strand orientation.
ISSN:1359-7345
1364-548X
DOI:10.1039/b312321a