Inhibitory Effect of Natural Phenolic Lipids upon NAD-Dependent Dehydrogenases and on Triglyceride Accumulation in 3T3-L1 Cells in Culture

Alkylresorcinols are phenolic lipids present at levels of 0.03−0.15% in wheat and rye grains and almost 10 times higher in respective bran products. Despite numerous studies on the influence of dietary fibers on the regulation of energy metabolism, this issue still remains controversial. The objecti...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2004-01, Vol.52 (2), p.246-250
Main Authors: Rejman, Joanna, Kozubek, Arkadiusz
Format: Article
Language:English
Subjects:
3T3-L1 Cells
Adipocytes - drug effects
Adipocytes - enzymology
Adipocytes - metabolism
Agronomy. Soil science and plant productions
Animals
Biological and medical sciences
Chemical constitution
Economic plant physiology
Enzyme Inhibitors - pharmacology
Fundamental and applied biological sciences. Psychology
Lipids - pharmacology
Mice
NAD - pharmacology
Oxidoreductases - antagonists & inhibitors
Resorcinols - pharmacology
Secale - chemistry
Triglycerides - metabolism
Triticum - chemistry
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Summary:Alkylresorcinols are phenolic lipids present at levels of 0.03−0.15% in wheat and rye grains and almost 10 times higher in respective bran products. Despite numerous studies on the influence of dietary fibers on the regulation of energy metabolism, this issue still remains controversial. The objective of our current studies was to investigate whether 5-n-alk(en)ylresorcinols, natural phenolic components of high fiber human diets, may be considered as natural regulators of excessive fat accumulation. Our studies revealed that 5-n-alk(en)ylresorcinols isolated from wheat and rye bran inhibit glycerol-3-phosphate dehydrogenase, the key enzyme in triglyceride synthesis in adipocytes, specifically and effectively. Further in vitro studies showed that these compounds also prevent triglyceride accumulation in 3T3-L1 cells. The most effective compound in both systems was 5-n-heneicosylresorcinol. The results indicate that the potential to prevent triglyceride accumulation increases with the hydrophobicity of the phenolic inhibitor. Keywords: Phenolic lipids; resorcinolic lipids; alkylresorcinols; dehydrogenases; triglyceride accumulation; cereals; high fiber diet
ISSN:0021-8561
1520-5118
DOI:10.1021/jf034745a