Anti-nucleosome antibodies in patients with systemic lupus erythematosus of recent onset. Potential utility as a diagnostic tool and disease activity marker

Objective. To compare the utility of anti-chromatin antibodies for the diagnosis of systemic lupus erythematosus (SLE) and as markers of disease activity. Methods. We included 73 consecutive patients (62 female) with SLE (four or more ACR criteria) of recent onset (

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2004-02, Vol.43 (2), p.220-224
Main Authors: Simón, J. A., Cabiedes, J., Ortiz, E., Alcocer-Varela, J., Sánchez-Guerrero, J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anti-chromatin antibodies
Anti-nucleosome antibodies
Antibodies, Antinuclear - blood
Autoimmune Diseases - diagnosis
Biological and medical sciences
Biomarkers - blood
Chromatin - immunology
Cross-Sectional Studies
Diagnosis
Diagnosis, Differential
Disease activity
Diseases of the osteoarticular system
Female
Humans
Lupus Erythematosus, Systemic - diagnosis
Male
Medical sciences
Nucleosomes - immunology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Sensitivity and Specificity
Severity of Illness Index
Systemic lupus erythematosus
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Description
Summary:Objective. To compare the utility of anti-chromatin antibodies for the diagnosis of systemic lupus erythematosus (SLE) and as markers of disease activity. Methods. We included 73 consecutive patients (62 female) with SLE (four or more ACR criteria) of recent onset (
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keh024