Synergies of microtissue design, viral transduction and adjustable transgene expression for regenerative medicine

In the past decade, regenerative medicine has evolved as an interdisciplinary field, integrating expertise from the medical, life- and material-science communities. Recent advances in tissue engineering, gene therapy, gene-function analysis, animal-free drug testing, drug discovery, biopharmaceutica...

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Bibliographic Details
Published in:Biotechnology and applied biochemistry 2004-02, Vol.39 (Pt 1), p.3-16
Main Authors: Kelm, Jens M, Kramer, Beat P, Gonzalez-Nicolini, Valeria, Ley, Bettina, Fussenegger, Martin
Format: Article
Language:English
Subjects:
Animals
Gene Expression Regulation
Gene Transfer Techniques
Genetic Therapy
Genetic Vectors - genetics
Humans
Regenerative Medicine - methods
Tissue Engineering - methods
Transduction, Genetic - methods
Transgenes - genetics
Viruses - genetics
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Summary:In the past decade, regenerative medicine has evolved as an interdisciplinary field, integrating expertise from the medical, life- and material-science communities. Recent advances in tissue engineering, gene therapy, gene-function analysis, animal-free drug testing, drug discovery, biopharmaceutical manufacturing and cell-phenotype engineering have capitalized on a core technology portfolio including artificial microtissue design, viral transduction and precise transcription dosing of therapeutic or phenotype-modulating transgenes. We provide a detailed overview on recent progress in these core technologies and comment on their synergistic impact on current and future human therapies.
ISSN:0885-4513
DOI:10.1042/BA20030124