Chitosan supports the initial attachment and spreading of osteoblasts preferentially over fibroblasts

The aim of this study was to determine chitosan's effect on osteoblast and fibroblast cell attachment. Mouse MC3T3-E1 osteoblasts and 3T3 fibroblasts were grown in the presence of serum on two commercially available chitosans, Chitosan-H (CH) and Protasan CL212 (PR). Cell attachment and immunof...

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Bibliographic Details
Published in:Biomaterials 2004-05, Vol.25 (11), p.2075-2079
Main Authors: Fakhry, Ali, Schneider, Galen B., Zaharias, Rebecca, Şenel, Sevda
Format: Article
Language:English
Subjects:
3T3 Cells
Animals
Cell Adhesion - physiology
Cell culture
Cell Line
Cell Movement - physiology
Chitosan
Coated Materials, Biocompatible - chemistry
Drug delivery
Fibroblasts
Fibroblasts - cytology
Fibroblasts - physiology
Materials Testing
Mice
Osteoblasts
Osteoblasts - cytology
Osteoblasts - physiology
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Summary:The aim of this study was to determine chitosan's effect on osteoblast and fibroblast cell attachment. Mouse MC3T3-E1 osteoblasts and 3T3 fibroblasts were grown in the presence of serum on two commercially available chitosans, Chitosan-H (CH) and Protasan CL212 (PR). Cell attachment and immunofluorescent analysis at various time points were done to analyze initial phenotypic profiles. At 1 h, significantly ( P
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2003.08.068