Spirostanol and Furostanol Glycosides from the Fresh Tubers of Polianthes tuberosa

Six new steroid glycosidestwo spirostanols, polianthosides B and C (1, 2), and four furostanols, polianthosides D−G (3−6)were isolated from the fresh tubers of Polianthes tuberosa, together with seven known spirostanols (7−13) and a known furostanol (14) saponins. Their structures were elucidated...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-01, Vol.67 (1), p.5-9
Main Authors: Jin, Jian-Ming, Zhang, Ying-Jun, Yang, Chong-Ren
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Asparagaceae - chemistry
Biological and medical sciences
Drug Screening Assays, Antitumor
General pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
HeLa Cells
Humans
Hydrolysis
Medical sciences
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
Sterols - chemistry
Sterols - isolation & purification
Sterols - pharmacology
Tumor Cells, Cultured
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Summary:Six new steroid glycosidestwo spirostanols, polianthosides B and C (1, 2), and four furostanols, polianthosides D−G (3−6)were isolated from the fresh tubers of Polianthes tuberosa, together with seven known spirostanols (7−13) and a known furostanol (14) saponins. Their structures were elucidated on the basis of spectroscopic analysis and the results of acidic and enzymatic hydrolysis. The cytotoxic activities of 1−14 against HeLa cells are reported.
ISSN:0163-3864
1520-6025
DOI:10.1021/np034028a