Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum

A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four met...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-01, Vol.67 (1), p.98-102
Main Authors: Fujimoto, H, Sumino, M, Okuyama, E, Ishibashi, M
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - chemistry
Adjuvants, Immunologic - isolation & purification
Adjuvants, Immunologic - pharmacology
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Biological and medical sciences
Chaetomium - chemistry
Chaetomium seminudum
Disulfides
General pharmacology
Heterocyclic Compounds, 4 or More Rings - chemistry
Heterocyclic Compounds, 4 or More Rings - isolation & purification
Heterocyclic Compounds, 4 or More Rings - pharmacology
Indole Alkaloids
Japan
Lymphocytes - drug effects
Medical sciences
Mice
Molecular Structure
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Spleen - cytology
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Summary:A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four metabolites, 1 and 2 have been deduced as the immunosuppressive features of this fungus.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0302201