Significance of chymase inhibition for prevention of adhesion formation

To clarify the role of chymase in adhesion formation, we investigated whether a chymase inhibitor could prevent adhesion formation after surgery in hamsters. Hamsters received a lesion produced by uterus scraping. A specific chymase inhibitor, 2-[4-(5-fluoro-3-methylbenzo[ b]thiophen-2-yl)sulfonamid...

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Bibliographic Details
Published in:European journal of pharmacology 2004-01, Vol.484 (2), p.357-359
Main Authors: Okamoto, Yukiko, Takai, Shinji, Miyazaki, Mizuo
Format: Article
Language:English
Subjects:
Adhesion
Animals
Biological and medical sciences
Chymase
Chymase inhibitor
Chymases
Cricetinae
Female
Medical sciences
Mesocricetus
Oxazoles - pharmacology
Oxazoles - therapeutic use
Peritoneal Cavity - pathology
Peritoneal Cavity - surgery
Pharmacology. Drug treatments
Serine Endopeptidases - metabolism
Serine Proteinase Inhibitors - pharmacology
Serine Proteinase Inhibitors - therapeutic use
Sulfonamides - pharmacology
Sulfonamides - therapeutic use
Surgery
Tissue Adhesions - enzymology
Tissue Adhesions - prevention & control
Uterus - drug effects
Uterus - enzymology
Uterus - pathology
Uterus - surgery
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Summary:To clarify the role of chymase in adhesion formation, we investigated whether a chymase inhibitor could prevent adhesion formation after surgery in hamsters. Hamsters received a lesion produced by uterus scraping. A specific chymase inhibitor, 2-[4-(5-fluoro-3-methylbenzo[ b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid (TY-51184), or placebo was injected into the abdomen before closing and scores for adhesion formation were assessed at 1, 4, and 12 weeks. A single peritoneal administration of TY-51184 significantly decreased the adhesion scores even at 12 weeks (placebo, 2.80±0.20; chymase inhibitor, 1.60±0.31). Thus, chymase inhibitors may be a novel strategy to prevent adhesion formation.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2003.11.009