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Significance of chymase inhibition for prevention of adhesion formation
To clarify the role of chymase in adhesion formation, we investigated whether a chymase inhibitor could prevent adhesion formation after surgery in hamsters. Hamsters received a lesion produced by uterus scraping. A specific chymase inhibitor, 2-[4-(5-fluoro-3-methylbenzo[ b]thiophen-2-yl)sulfonamid...
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| Published in: | European journal of pharmacology 2004-01, Vol.484 (2), p.357-359 |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c454t-f33be2e39cf398624333b6d65266b4543f90bd9ce0539280bb571960843720473 |
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| cites | cdi_FETCH-LOGICAL-c454t-f33be2e39cf398624333b6d65266b4543f90bd9ce0539280bb571960843720473 |
| container_end_page | 359 |
| container_issue | 2 |
| container_start_page | 357 |
| container_title | European journal of pharmacology |
| container_volume | 484 |
| creator | Okamoto, Yukiko Takai, Shinji Miyazaki, Mizuo |
| description | To clarify the role of chymase in adhesion formation, we investigated whether a chymase inhibitor could prevent adhesion formation after surgery in hamsters. Hamsters received a lesion produced by uterus scraping. A specific chymase inhibitor, 2-[4-(5-fluoro-3-methylbenzo[
b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid (TY-51184), or placebo was injected into the abdomen before closing and scores for adhesion formation were assessed at 1, 4, and 12 weeks. A single peritoneal administration of TY-51184 significantly decreased the adhesion scores even at 12 weeks (placebo, 2.80±0.20; chymase inhibitor, 1.60±0.31). Thus, chymase inhibitors may be a novel strategy to prevent adhesion formation. |
| doi_str_mv | 10.1016/j.ejphar.2003.11.009 |
| format | article |
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b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid (TY-51184), or placebo was injected into the abdomen before closing and scores for adhesion formation were assessed at 1, 4, and 12 weeks. A single peritoneal administration of TY-51184 significantly decreased the adhesion scores even at 12 weeks (placebo, 2.80±0.20; chymase inhibitor, 1.60±0.31). Thus, chymase inhibitors may be a novel strategy to prevent adhesion formation.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2003.11.009</identifier><identifier>PMID: 14744623</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adhesion ; Animals ; Biological and medical sciences ; Chymase ; Chymase inhibitor ; Chymases ; Cricetinae ; Female ; Medical sciences ; Mesocricetus ; Oxazoles - pharmacology ; Oxazoles - therapeutic use ; Peritoneal Cavity - pathology ; Peritoneal Cavity - surgery ; Pharmacology. Drug treatments ; Serine Endopeptidases - metabolism ; Serine Proteinase Inhibitors - pharmacology ; Serine Proteinase Inhibitors - therapeutic use ; Sulfonamides - pharmacology ; Sulfonamides - therapeutic use ; Surgery ; Tissue Adhesions - enzymology ; Tissue Adhesions - prevention & control ; Uterus - drug effects ; Uterus - enzymology ; Uterus - pathology ; Uterus - surgery</subject><ispartof>European journal of pharmacology, 2004-01, Vol.484 (2), p.357-359</ispartof><rights>2003 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-f33be2e39cf398624333b6d65266b4543f90bd9ce0539280bb571960843720473</citedby><cites>FETCH-LOGICAL-c454t-f33be2e39cf398624333b6d65266b4543f90bd9ce0539280bb571960843720473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15478394$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14744623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okamoto, Yukiko</creatorcontrib><creatorcontrib>Takai, Shinji</creatorcontrib><creatorcontrib>Miyazaki, Mizuo</creatorcontrib><title>Significance of chymase inhibition for prevention of adhesion formation</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>To clarify the role of chymase in adhesion formation, we investigated whether a chymase inhibitor could prevent adhesion formation after surgery in hamsters. Hamsters received a lesion produced by uterus scraping. A specific chymase inhibitor, 2-[4-(5-fluoro-3-methylbenzo[
b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid (TY-51184), or placebo was injected into the abdomen before closing and scores for adhesion formation were assessed at 1, 4, and 12 weeks. A single peritoneal administration of TY-51184 significantly decreased the adhesion scores even at 12 weeks (placebo, 2.80±0.20; chymase inhibitor, 1.60±0.31). Thus, chymase inhibitors may be a novel strategy to prevent adhesion formation.</description><subject>Adhesion</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chymase</subject><subject>Chymase inhibitor</subject><subject>Chymases</subject><subject>Cricetinae</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Oxazoles - pharmacology</subject><subject>Oxazoles - therapeutic use</subject><subject>Peritoneal Cavity - pathology</subject><subject>Peritoneal Cavity - surgery</subject><subject>Pharmacology. Drug treatments</subject><subject>Serine Endopeptidases - metabolism</subject><subject>Serine Proteinase Inhibitors - pharmacology</subject><subject>Serine Proteinase Inhibitors - therapeutic use</subject><subject>Sulfonamides - pharmacology</subject><subject>Sulfonamides - therapeutic use</subject><subject>Surgery</subject><subject>Tissue Adhesions - enzymology</subject><subject>Tissue Adhesions - prevention & control</subject><subject>Uterus - drug effects</subject><subject>Uterus - enzymology</subject><subject>Uterus - pathology</subject><subject>Uterus - surgery</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kE1Lw0AQhhdRtFb_gUguekuc_UqyF0GKX1DwoJ6XzWbWbmmSutsK_nu3NuDN0zAzzzsMDyEXFAoKtLxZFrhcL0woGAAvKC0A1AGZ0LpSOVSUHZIJABU5U0qdkNMYlwAgFZPH5ISKSoiS8Ql5fPUfvXfemt5iNrjMLr47EzHz_cI3fuOHPnNDyNYBv7D_bRNk2gXGcdWZ3fSMHDmzing-1il5f7h_mz3l85fH59ndPLdCik3uOG-QIVfWcVWXTPA0KNtSsrJsEsGdgqZVFkFyxWpoGllRVUIteMVAVHxKrvd312H43GLc6M5Hi6uV6XHYRl0DpZJJmkCxB20YYgzo9Dr4zoRvTUHvBOql3gvUO4GaUp0EptjleH_bdNj-hUZjCbgaAROtWbmQxPn4x0lR1VyJxN3uOUw2vjwGHa3HJLn1Ae1Gt4P__5MfjaCPIA</recordid><startdate>20040126</startdate><enddate>20040126</enddate><creator>Okamoto, Yukiko</creator><creator>Takai, Shinji</creator><creator>Miyazaki, Mizuo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040126</creationdate><title>Significance of chymase inhibition for prevention of adhesion formation</title><author>Okamoto, Yukiko ; Takai, Shinji ; Miyazaki, Mizuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-f33be2e39cf398624333b6d65266b4543f90bd9ce0539280bb571960843720473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adhesion</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chymase</topic><topic>Chymase inhibitor</topic><topic>Chymases</topic><topic>Cricetinae</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Oxazoles - pharmacology</topic><topic>Oxazoles - therapeutic use</topic><topic>Peritoneal Cavity - pathology</topic><topic>Peritoneal Cavity - surgery</topic><topic>Pharmacology. Drug treatments</topic><topic>Serine Endopeptidases - metabolism</topic><topic>Serine Proteinase Inhibitors - pharmacology</topic><topic>Serine Proteinase Inhibitors - therapeutic use</topic><topic>Sulfonamides - pharmacology</topic><topic>Sulfonamides - therapeutic use</topic><topic>Surgery</topic><topic>Tissue Adhesions - enzymology</topic><topic>Tissue Adhesions - prevention & control</topic><topic>Uterus - drug effects</topic><topic>Uterus - enzymology</topic><topic>Uterus - pathology</topic><topic>Uterus - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okamoto, Yukiko</creatorcontrib><creatorcontrib>Takai, Shinji</creatorcontrib><creatorcontrib>Miyazaki, Mizuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okamoto, Yukiko</au><au>Takai, Shinji</au><au>Miyazaki, Mizuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of chymase inhibition for prevention of adhesion formation</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2004-01-26</date><risdate>2004</risdate><volume>484</volume><issue>2</issue><spage>357</spage><epage>359</epage><pages>357-359</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>To clarify the role of chymase in adhesion formation, we investigated whether a chymase inhibitor could prevent adhesion formation after surgery in hamsters. Hamsters received a lesion produced by uterus scraping. A specific chymase inhibitor, 2-[4-(5-fluoro-3-methylbenzo[
b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid (TY-51184), or placebo was injected into the abdomen before closing and scores for adhesion formation were assessed at 1, 4, and 12 weeks. A single peritoneal administration of TY-51184 significantly decreased the adhesion scores even at 12 weeks (placebo, 2.80±0.20; chymase inhibitor, 1.60±0.31). Thus, chymase inhibitors may be a novel strategy to prevent adhesion formation.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>14744623</pmid><doi>10.1016/j.ejphar.2003.11.009</doi><tpages>3</tpages></addata></record> |
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| subjects | Adhesion Animals Biological and medical sciences Chymase Chymase inhibitor Chymases Cricetinae Female Medical sciences Mesocricetus Oxazoles - pharmacology Oxazoles - therapeutic use Peritoneal Cavity - pathology Peritoneal Cavity - surgery Pharmacology. Drug treatments Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - pharmacology Serine Proteinase Inhibitors - therapeutic use Sulfonamides - pharmacology Sulfonamides - therapeutic use Surgery Tissue Adhesions - enzymology Tissue Adhesions - prevention & control Uterus - drug effects Uterus - enzymology Uterus - pathology Uterus - surgery |
| title | Significance of chymase inhibition for prevention of adhesion formation |
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