Development of a Quantitative Structure−Activity Relationship Model for Inhibition of Gram-positive Bacterial Cell Growth by Biarylamides

A set of compounds consisting of a new and diverse collection of biarylamides was examined using quantitative structure−activity relationship techniques for the purpose of developing a model to describe inhibition of gram-positive bacterial growth (minimum inhibition concentration). The model was so...

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Published in:Journal of Chemical Information and Computer Sciences 2004-01, Vol.44 (1), p.221-229
Main Authors: Stanton, David T, Madhav, Prakash J, Wilson, Larry J, Morris, Timothy W, Hershberger, Paul M, Parker, Christian N
Format: Article
Language:English
Subjects:
Amides - pharmacology
Cell Division - drug effects
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - growth & development
Quantitative Structure-Activity Relationship
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creator Stanton, David T
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description A set of compounds consisting of a new and diverse collection of biarylamides was examined using quantitative structure−activity relationship techniques for the purpose of developing a model to describe inhibition of gram-positive bacterial growth (minimum inhibition concentration). The model was sought in order to obtain insight for designing new molecules. A detailed analysis of the underlying structure−activity relationship helped provide insight concerning which structural features of the molecules modulated the activity of the compounds against gram-positive organisms.
doi_str_mv 10.1021/ci034158p
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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Amides - pharmacology
Cell Division - drug effects
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - growth & development
Quantitative Structure-Activity Relationship
title Development of a Quantitative Structure−Activity Relationship Model for Inhibition of Gram-positive Bacterial Cell Growth by Biarylamides
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