Kalirin expression is regulated by multiple promoters

Kalirin is a multidomain guanine nucleotide exchange factor for small GTPbinding proteins of the Rho family. It is expressed in multiple isoforms that contain different combinations of functional domains and display a complex pattern of expression during brain development. In addition to the isoform...

Full description

Saved in:
Bibliographic Details
Published in:Journal of molecular neuroscience 2004-01, Vol.22 (1-2), p.51-62
Main Authors: McPherson, Clifton E, Eipper, Betty A, Mains, Richard E
Format: Article
Language:English
Subjects:
Alternative Splicing - genetics
Amino Acid Sequence
Animals
Carrier Proteins - biosynthesis
Carrier Proteins - genetics
Cells, Cultured
Exons - genetics
Genes, Regulator - genetics
Guanine Nucleotide Exchange Factors - biosynthesis
Guanine Nucleotide Exchange Factors - genetics
Humans
Molecular Sequence Data
Promoter Regions, Genetic - genetics
Protein Isoforms - biosynthesis
Protein Isoforms - genetics
Protein Structure, Tertiary - genetics
Proteins
Rats
Rodents
Transcriptional Activation - genetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Kalirin is a multidomain guanine nucleotide exchange factor for small GTPbinding proteins of the Rho family. It is expressed in multiple isoforms that contain different combinations of functional domains and display a complex pattern of expression during brain development. In addition to the isoforms generated through alternative splicing, we have identified multiple transcriptional start sites in rats and humans. These multiple transcriptional start sites result in full-length Kalirin transcripts possessing different 5' ends encoding proteins with differing amino termini. These alternative first exons display different patterns of expression in developing rats and humans and in cultured cells. Most of these alternate first exons lie >100 kb upstream of exon 2 in both rats and humans. Comparisons of the rat and human Kalirin promoter regions reveal numerous shared potential regulatory elements.
ISSN:0895-8696
0895-8696
1559-1166
DOI:10.1385/JMN:22:1-2:51