Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography

The possibility of measuring a full Doppler flow depth profile in parallel by use of frequency-domain optical coherence tomography is demonstrated. The method is based on a local phase analysis of the backscattered signal and allows for imaging of bidirectional Doppler flow. The Doppler frequency li...

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Bibliographic Details
Published in:Optics letters 2004-01, Vol.29 (2), p.171-173
Main Authors: Leitgeb, Rainer A, Schmetterer, Leopold, Hitzenberger, Christoph K, Fercher, Adolf F, Berisha, Fatma, Wojtkowski, Maciej, Bajraszewski, Tomasz
Format: Article
Language:English
Subjects:
Blood Cells - physiology
Blood Cells - radiation effects
Blood Vessels - physiology
Computer Systems
Fourier Analysis
Humans
In Vitro Techniques
Microspheres
Models, Cardiovascular
Regional Blood Flow
Rheology
Scattering, Radiation
Tomography, Optical Coherence
Ultrasonography, Doppler, Color
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Summary:The possibility of measuring a full Doppler flow depth profile in parallel by use of frequency-domain optical coherence tomography is demonstrated. The method is based on a local phase analysis of the backscattered signal and allows for imaging of bidirectional Doppler flow. The Doppler frequency limit is 5 kHz for the presented measurements and is set by half of the frame rate of the CCD detector array. We measured the flow of 0.3-microm microspheres suspended in distilled water at controlled flow rates and in vitro human blood flow through a 200-microm capillary with a real-time color-encoded Doppler tomogram rate of 2-3/s.
ISSN:0146-9592
1539-4794
DOI:10.1364/ol.29.000171