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Neuregulin-1 induces a negative inotropic effect in cardiac muscle: Role of nitric oxide synthase
Deficient cardiac neuregulin/ErbB signaling increases susceptibility to heart failure. In this study, we examined the effects of neuregulin-1 (NRG-1) on myocardial contractility. NRG-1 (alpha and beta isoforms) induced a negative inotropic effect in isolated rabbit papillary muscles and a rightward...
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| Published in: | Circulation (New York, N.Y.) N.Y.), 2004-01, Vol.109 (3), p.324-326 |
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| Main Authors: | , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c413t-e22b103d60705f656efd4e07465ca2ce5153e086683cb721506d35e36aa0acc53 |
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| cites | cdi_FETCH-LOGICAL-c413t-e22b103d60705f656efd4e07465ca2ce5153e086683cb721506d35e36aa0acc53 |
| container_end_page | 326 |
| container_issue | 3 |
| container_start_page | 324 |
| container_title | Circulation (New York, N.Y.) |
| container_volume | 109 |
| creator | LEMMENS, Katrien FRANSEN, Paul SYS, Stanislas U BRUTSAERT, Dirk L DE KEULENAER, Gilles W |
| description | Deficient cardiac neuregulin/ErbB signaling increases susceptibility to heart failure. In this study, we examined the effects of neuregulin-1 (NRG-1) on myocardial contractility.
NRG-1 (alpha and beta isoforms) induced a negative inotropic effect in isolated rabbit papillary muscles and a rightward shift of the dose-response curve to isoproterenol. Both effects were attenuated by L-NMMA, which suggests a role for NO synthase. In cultured rat cardiomyocytes, NRG-1beta enhanced nitrite production and resulted in phosphorylation of endothelial NO synthase and the serine/threonine kinase Akt.
NRG-1 has negative inotropic effects that are preserved during beta-adrenergic stimulation and activates endothelial NO synthase in cardiomyocytes. |
| doi_str_mv | 10.1161/01.CIR.0000114521.88547.5E |
| format | article |
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NRG-1 (alpha and beta isoforms) induced a negative inotropic effect in isolated rabbit papillary muscles and a rightward shift of the dose-response curve to isoproterenol. Both effects were attenuated by L-NMMA, which suggests a role for NO synthase. In cultured rat cardiomyocytes, NRG-1beta enhanced nitrite production and resulted in phosphorylation of endothelial NO synthase and the serine/threonine kinase Akt.
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NRG-1 (alpha and beta isoforms) induced a negative inotropic effect in isolated rabbit papillary muscles and a rightward shift of the dose-response curve to isoproterenol. Both effects were attenuated by L-NMMA, which suggests a role for NO synthase. In cultured rat cardiomyocytes, NRG-1beta enhanced nitrite production and resulted in phosphorylation of endothelial NO synthase and the serine/threonine kinase Akt.
NRG-1 has negative inotropic effects that are preserved during beta-adrenergic stimulation and activates endothelial NO synthase in cardiomyocytes.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cells, Cultured</subject><subject>Culture Techniques</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Medical sciences</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardium - cytology</subject><subject>Myocytes, Cardiac - drug effects</subject><subject>Myocytes, Cardiac - enzymology</subject><subject>Neuregulin-1 - pharmacology</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide Synthase - metabolism</subject><subject>Nitric Oxide Synthase - physiology</subject><subject>Nitric Oxide Synthase Type III</subject><subject>Protein-Serine-Threonine Kinases</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-akt</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpdkV1L7DAQhoMoun78BQmC3rUnk6-23smyegQ5guh1yKZTjXSbNWlF_71RFxZOboa8PDMJ8xByBqwE0PCHQTm_fShZPgBScSjrWsmqVIsdMgPFZSGVaHbJLANNUQnOD8hhSq_5qkWl9skByJxWks-I_YdTxOep90MB1A_t5DBRSwd8tqN_xxyFMYa1dxS7Dt2YA-psbL11dDUl1-MlfQg90tDRwY8xg-HDt0jT5zC-2ITHZK-zfcKTTT0iT9eLx_nf4u7-5nZ-dVc4CWIskPMlMNFqVjHVaaWxayWySmrlLHeoQAlktda1cMuKg2K6FQqFtpZZ55Q4Ihe_c9cxvE2YRrPyyWHf2wHDlEydl1WLhmXw7D_wNUxxyH8zHLiumrrhGbr8hVwMKUXszDr6lY2fBpj5tmAYmGzBbC2YHwtGLXLz6eaFabnCdtu6WXsGzjeATc72XbSD82nLKc1qnmV9AUAjj1M</recordid><startdate>20040127</startdate><enddate>20040127</enddate><creator>LEMMENS, Katrien</creator><creator>FRANSEN, Paul</creator><creator>SYS, Stanislas U</creator><creator>BRUTSAERT, Dirk L</creator><creator>DE KEULENAER, Gilles W</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20040127</creationdate><title>Neuregulin-1 induces a negative inotropic effect in cardiac muscle: Role of nitric oxide synthase</title><author>LEMMENS, Katrien ; FRANSEN, Paul ; SYS, Stanislas U ; BRUTSAERT, Dirk L ; DE KEULENAER, Gilles W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-e22b103d60705f656efd4e07465ca2ce5153e086683cb721506d35e36aa0acc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cells, Cultured</topic><topic>Culture Techniques</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Medical sciences</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardium - cytology</topic><topic>Myocytes, Cardiac - drug effects</topic><topic>Myocytes, Cardiac - enzymology</topic><topic>Neuregulin-1 - pharmacology</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nitric Oxide Synthase - metabolism</topic><topic>Nitric Oxide Synthase - physiology</topic><topic>Nitric Oxide Synthase Type III</topic><topic>Protein-Serine-Threonine Kinases</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-akt</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEMMENS, Katrien</creatorcontrib><creatorcontrib>FRANSEN, Paul</creatorcontrib><creatorcontrib>SYS, Stanislas U</creatorcontrib><creatorcontrib>BRUTSAERT, Dirk L</creatorcontrib><creatorcontrib>DE KEULENAER, Gilles W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEMMENS, Katrien</au><au>FRANSEN, Paul</au><au>SYS, Stanislas U</au><au>BRUTSAERT, Dirk L</au><au>DE KEULENAER, Gilles W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuregulin-1 induces a negative inotropic effect in cardiac muscle: Role of nitric oxide synthase</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2004-01-27</date><risdate>2004</risdate><volume>109</volume><issue>3</issue><spage>324</spage><epage>326</epage><pages>324-326</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Deficient cardiac neuregulin/ErbB signaling increases susceptibility to heart failure. In this study, we examined the effects of neuregulin-1 (NRG-1) on myocardial contractility.
NRG-1 (alpha and beta isoforms) induced a negative inotropic effect in isolated rabbit papillary muscles and a rightward shift of the dose-response curve to isoproterenol. Both effects were attenuated by L-NMMA, which suggests a role for NO synthase. In cultured rat cardiomyocytes, NRG-1beta enhanced nitrite production and resulted in phosphorylation of endothelial NO synthase and the serine/threonine kinase Akt.
NRG-1 has negative inotropic effects that are preserved during beta-adrenergic stimulation and activates endothelial NO synthase in cardiomyocytes.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>14732742</pmid><doi>10.1161/01.CIR.0000114521.88547.5E</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0009-7322 |
| ispartof | Circulation (New York, N.Y.), 2004-01, Vol.109 (3), p.324-326 |
| issn | 0009-7322 1524-4539 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Animals Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cells, Cultured Culture Techniques Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Medical sciences Myocardial Contraction - drug effects Myocardium - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Neuregulin-1 - pharmacology Nitric Oxide - biosynthesis Nitric Oxide Synthase - metabolism Nitric Oxide Synthase - physiology Nitric Oxide Synthase Type III Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Rabbits Rats Rats, Sprague-Dawley |
| title | Neuregulin-1 induces a negative inotropic effect in cardiac muscle: Role of nitric oxide synthase |
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