Simulation of some short-term control mechanisms in cardiovascular physiology

The equivalent electronic circuit, developed to simulate cardiovascular physiology, is upgraded to incorporate negative feedback loops. In this way homeostasis of the arterial pressure is simulated in exercise, in haemorrhage, in the insufficiency of the aortic valve, and in hypervolemia. The result...

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Bibliographic Details
Published in:Computers in biology and medicine 2004, Vol.34 (1), p.35-49
Main Authors: Podnar, T., Runovc, F., Milisav, Irina, Kordaš, M.
Format: Article
Language:English
Subjects:
Aortic Valve Insufficiency - physiopathology
Blood Volume - physiology
Cardiovascular Physiological Phenomena
Cardiovascular physiology
Computer applications
Computer Simulation
Electric Conductivity
Exercise - physiology
Hemorrhage - physiopathology
Homeostasis
Homeostasis - physiology
Humans
Medicine
Models, Cardiovascular
Simulations
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Summary:The equivalent electronic circuit, developed to simulate cardiovascular physiology, is upgraded to incorporate negative feedback loops. In this way homeostasis of the arterial pressure is simulated in exercise, in haemorrhage, in the insufficiency of the aortic valve, and in hypervolemia. The results show that homeostasis supports the cardiovascular system by modulating Starling mechanism(s) in exercise, haemorrhage and hypervolemia. In aortic insufficiency it seems that only Starling mechanism(s) can maintain cardiac output and arterial pressure.
ISSN:0010-4825
1879-0534
DOI:10.1016/S0010-4825(03)00023-4