Obesity Wars: Molecular Progress Confronts an Expanding Epidemic

The worldwide prevalence of obesity is increasing at an alarming rate, with major adverse consequences for human health. This “obesity epidemic” is paralleled by a rapid and substantive increase in our understanding of molecular pathways and physiologic systems underlying the regulation of energy ba...

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Bibliographic Details
Published in:Cell 2004-01, Vol.116 (2), p.337-350
Main Author: Flier, Jeffrey S
Format: Article
Language:English
Subjects:
Animals
Body Weight
Brain - metabolism
Brain - physiology
Digestive System
Disease Outbreaks
Energy Metabolism
Humans
Hypothalamic Hormones - physiology
Leptin - physiology
Melanins - physiology
Models, Biological
Obesity - epidemiology
Obesity - genetics
Pituitary Hormones - physiology
Receptors, Cell Surface - physiology
Receptors, Leptin
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Summary:The worldwide prevalence of obesity is increasing at an alarming rate, with major adverse consequences for human health. This “obesity epidemic” is paralleled by a rapid and substantive increase in our understanding of molecular pathways and physiologic systems underlying the regulation of energy balance. While efforts to address the environmental factors that are responsible for the recent “epidemic” must continue, new molecular and physiologic insights into this system offer exciting possibilities for future development of successful therapies.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(03)01081-X