Basal FSH concentrations as a marker of ovarian ageing are not related to pregnancy outcome in a general population of women over 30 years

BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies. However, there have been no prospective studies evaluating the incidence of aneuploidies in relation to basal FSH concentrations. Since the majority of aneuploid conceptions end in early...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2004-02, Vol.19 (2), p.430-434
Main Authors: van Montfrans, J.M., van Hooff, M.H.A., Huirne, J.A., Tanahatoe, S.J., Sadrezadeh, S., Martens, F., van Vugt, J.M.G., Lambalk, C.B.
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - blood
abortion/age/aneuploidy/FSH/subfertility
Adult
Aging
Aneuploidy
Biological and medical sciences
Biomarkers - blood
Chorionic Gonadotropin - urine
Embryology: invertebrates and vertebrates. Teratology
Female
Follicle Stimulating Hormone - blood
Fundamental and applied biological sciences. Psychology
Humans
Menstrual Cycle
Ovary - physiology
Pregnancy
Pregnancy Outcome
Prospective Studies
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Summary:BACKGROUND: Previous studies suggest that elevated basal FSH concentrations are related to aneuploid pregnancies. However, there have been no prospective studies evaluating the incidence of aneuploidies in relation to basal FSH concentrations. Since the majority of aneuploid conceptions end in early pregnancy loss or abortion of a recognized pregnancy, these determinants are appropriate intermediate end‐points to study aneuploidy. METHODS: We performed a prospective study in 129 women without a history of subfertility pursuing a spontaneous pregnancy. Basal FSH concentrations were measured during three menstrual cycles. Urinary HCG levels were measured during menstruation for a maximum of six menstrual cycles, to detect early pregnancy loss. We estimated the effect of basal FSH concentrations on pregnancy outcome, taking into account possible confounders. RESULTS: We observed no significant effect of basal FSH concentrations on the incidence of early pregnancy loss or abortion of clinically recognized pregnancies. CONCLUSIONS: We conclude that in a population of women without a history of subfertility, pursuing a spontaneous pregnancy, basal FSH concentrations are not related to the incidence of early pregnancy loss or abortions. This prospective study therefore fails to confirm a relationship between signs of decreased ovarian reserve and aneuploid pregnancies.
ISSN:0268-1161
1460-2350
1460-2350
DOI:10.1093/humrep/deh088