Human papillomavirus vaccines and prevention of cervical cancer

Cervical cancer and precancerous cervical lesions constitute a major problem in women's health. Every year 470,000 cases of cervical cancer are diagnosed worldwide, and about half the women afflicted will die. In the United States alone, approximately 14,000 cases of cervical cancer are diagnos...

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Bibliographic Details
Published in:Annual review of medicine 2004-01, Vol.55 (1), p.319-331
Main Authors: Jansen, Kathrin U, Shaw, Alan R
Format: Article
Language:English
Subjects:
Cancer Vaccines - therapeutic use
Cervical cancer
Female
Human papillomavirus
Humans
Medical diagnosis
Papillomaviridae - genetics
Papillomavirus Infections - complications
Papillomavirus Infections - prevention & control
Papillomavirus Vaccines
Uterine Cervical Neoplasms - prevention & control
Uterine Cervical Neoplasms - virology
Vaccines
Viruses
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Summary:Cervical cancer and precancerous cervical lesions constitute a major problem in women's health. Every year 470,000 cases of cervical cancer are diagnosed worldwide, and about half the women afflicted will die. In the United States alone, approximately 14,000 cases of cervical cancer are diagnosed each year despite the availability of screening and access to high-quality gynecological care. With the confirmation that cervical cancer is caused by an infectious agent, human papillomavirus, the possibility of fighting this disease with either prophylactic or therapeutic vaccination arose. This review describes advances in vaccine development and very promising first results for prophylactic vaccination against cervical cancer.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.med.55.091902.103520