Seeing Is Believing: The Bicoid Morphogen Gradient Matures

Although Cell has a long history of publishing some of the most significant advances in developmental biology, the back to back papers by Driever and Nüsslein-Volhard on the role of the Bicoid gradient in patterning the Drosophila embryo stand out as the first molecular demonstration of two of the l...

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Bibliographic Details
Published in:Cell 2004-01, Vol.116 (2), p.143-152
Main Authors: Ephrussi, Anne, Johnston, Daniel St
Format: Article
Language:English
Subjects:
Animals
Bicoid protein
Drosophila - embryology
Gene Expression Regulation, Developmental
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Homeodomain Proteins - physiology
Models, Biological
Protein Biosynthesis
RNA, Messenger - metabolism
Trans-Activators - genetics
Trans-Activators - physiology
Transcription, Genetic
Online Access:Get full text
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Summary:Although Cell has a long history of publishing some of the most significant advances in developmental biology, the back to back papers by Driever and Nüsslein-Volhard on the role of the Bicoid gradient in patterning the Drosophila embryo stand out as the first molecular demonstration of two of the longest standing concepts of the field, namely localized cytoplasmic determinants and morphogen gradients. Here we discuss the impact of this ground-breaking work and review recent results on bicoid mRNA localization and the dual role of Bicoid as a transcription and translation factor.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(04)00037-6