Immunohistochemical Localization of the Growth Hormone in Human Endometrium and Decidua

Problem:  Recent evidence of growth hormone (GH) receptor expression in rat endometrium and human myometrium have focused our attention on the role of the GH in endometrial development. We tested the expression of GH in the human endometrium throughout the menstrual cycle and during pregnancy. Metho...

Full description

Saved in:
Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2004-02, Vol.51 (2), p.112-116
Main Authors: Sbracia, Marco, Scarpellini, Fabio, Poverini, Roberto, Alò, Piero Lvigi, Rossi, Gabriele, Di Tondo, Ugo
Format: Article
Language:English
Subjects:
Abortion, Induced
Decidua
Decidua - immunology
Decidua - metabolism
Endometrium - immunology
Endometrium - metabolism
Female
growth hormone
Growth Hormone - biosynthesis
Growth Hormone - immunology
human endometrium
Humans
immunohistochemistry
Menstrual Cycle - immunology
Menstrual Cycle - metabolism
Pregnancy
Pregnancy Trimester, First - immunology
Pregnancy Trimester, First - metabolism
secretory phase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Problem:  Recent evidence of growth hormone (GH) receptor expression in rat endometrium and human myometrium have focused our attention on the role of the GH in endometrial development. We tested the expression of GH in the human endometrium throughout the menstrual cycle and during pregnancy. Method of study:  Immunohistochemical study was performed on endometrial specimens of fertile women in different periods of the menstrual cycle and in decidua of pregnant women. Results:  Glandular cells of the human endometrium were positive for GH in the mid and late luteal phase. Furthermore, the glandular cells of decidua showed intense staining for GH, while the stromal cells were negative. No immunostaining was expressed in the proliferative or early luteal phase. The intensity levels of staining for GH in decidual specimens were significantly higher than in glandular cells of secretory endometrium specimens (P 
ISSN:1046-7408
1600-0897
DOI:10.1046/j.8755-8920.2003.00127.x