First Functionalized MRI Contrast Agent Recognizing Vascular Lesions

A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weight...

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Bibliographic Details
Published in:Analytical Sciences 2004, Vol.20(1), pp.5-7
Main Authors: YAMAMOTO, Tatsuhiro, IKUTA, Kenjiro, OI, Keiji, ABE, Kohtaro, UWATOKU, Toyokazu, MURATA, Masaharu, SHIGETANI, Noboru, YOSHIMITSU, Kengo, SHIMOKAWA, Hiroaki, KATAYAMA, Yoshiki
Format: Article
Language:English
Subjects:
Contrast Media
Gadolinium DTPA - analogs & derivatives
Gadolinium DTPA - chemical synthesis
Gadolinium DTPA - chemistry
Humans
Magnetic Resonance Imaging
Vascular Diseases - diagnosis
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Summary:A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N′,N″,N″-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water’s protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.20.5