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Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol
Objective : To obtain information on the causes of age-related bone loss in men and the concomitant decline in calcium absorption. Design : Cross-sectional study. Setting : Adelaide, South Australia, Australia. Subjects : A total of 95 healthy, Caucasian men (age range 27–87 y). Results : Calcium ab...
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| Published in: | European journal of clinical nutrition 2004-02, Vol.58 (2), p.264-269 |
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| container_end_page | 269 |
| container_issue | 2 |
| container_start_page | 264 |
| container_title | European journal of clinical nutrition |
| container_volume | 58 |
| creator | Scopacasa, F Wishart, J M Horowitz, M Morris, H A Need, A G |
| description | Objective
: To obtain information on the causes of age-related bone loss in men and the concomitant decline in calcium absorption.
Design
: Cross-sectional study.
Setting
: Adelaide, South Australia, Australia.
Subjects
: A total of 95 healthy, Caucasian men (age range 27–87 y).
Results
: Calcium absorption declined with age (
r
=−0.46,
P
−0.21,
P |
| doi_str_mv | 10.1038/sj.ejcn.1601777 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_80124188</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A195751922</galeid><sourcerecordid>A195751922</sourcerecordid><originalsourceid>FETCH-LOGICAL-c581t-e621c429b7ffc3a6b530378fd4870c437fd7b3fd12d34a55cb42080bad1824a83</originalsourceid><addsrcrecordid>eNp90ktv1DAQAOAIgehSOHMCRUUtp2zt-BluVVUeUiUkBOfIcSZbrxx7sR0Qd344TjfSFtSiHCx5vhnbmSmKlxitMSLyPG7XsNVujTnCQohHxQpTwSvGKXpcrFDDaEUQEkfFsxi3COWgqJ8WR3mljaB8Vfz-AlYl413ZQfoJ4EqtrDbTWKou-rC7DSnXlxFC3rwNpmC8LY0rnQ-jsuUI7l0JP0wPTkM5-FCqDVRhLgx9dgliMi7DANHEpGaV_J1az4sng7IRXizrcfHt_dXXy4_V9ecPny4vrivNJE4V8BprWjedGAZNFO8YQUTIoadSIE2JGHrRkaHHdU-oYkx3tEYSdarHsqZKkuPibF93F_z3Kd-qHU3UYK1y4KfYSoRriuUM3_4XCkZlIzGnWb75R279FPJjY1tzWot8QY6zOnlQ4Ybn5hGWUbVHG2WhNW7wKSi9AQdBWe9gMHn7AjdMMNzUdfbre3z-ehiNvjfh7E7CDSibbqK309zj-Dc830MdfIwBhnYXzKjCrxajdp67Nm7bee7aZe5yxuvlgVM3Qn_wy6BlcLoAFXPjh5CnwMSDY1yQhs-F0N7FHHIbCIc_9fDZr_YpTqUpwKHmEv8D9x_6mw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219660135</pqid></control><display><type>article</type><title>Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol</title><source>EZB Electronic Journals Library</source><creator>Scopacasa, F ; Wishart, J M ; Horowitz, M ; Morris, H A ; Need, A G</creator><creatorcontrib>Scopacasa, F ; Wishart, J M ; Horowitz, M ; Morris, H A ; Need, A G</creatorcontrib><description>Objective
: To obtain information on the causes of age-related bone loss in men and the concomitant decline in calcium absorption.
Design
: Cross-sectional study.
Setting
: Adelaide, South Australia, Australia.
Subjects
: A total of 95 healthy, Caucasian men (age range 27–87 y).
Results
: Calcium absorption declined with age (
r
=−0.46,
P
<0.0001), as did 24-h urine calcium, phosphate and creatinine (
r
>−0.21,
P
<0.05 for all); serum calcitriol and 25 hydroxyvitamin D did not change with age. Calcium absorption was related to serum calcitriol (
r
=0.20,
P
=0.05). An inverse relation between the residual deviations in calcium absorption, after allowing for its dependence on calcitriol, and age (
F
=5.4,
P
<0.005) was observed. The 24-h urinary calcium, phosphate and creatinine were all related to calcium absorption (
r
>0.41,
P
<0.0001). Forearm bone density fell with age (
r
=−0.45,
P
<0.0001) but was not related to calcium absorption, or markers of bone turnover.
Conclusions
: In healthy Caucasian males (i) calcium absorption falls, but serum calcitriol does not change with age, (ii) the relation between calcium absorption and serum calcitriol changes with age, indicative of an intestinal resistance to calcitriol and (iii) calcium absorption is a significant determinant of 24-h urinary calcium excretion.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1601777</identifier><identifier>PMID: 14749746</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>25-Hydroxyvitamin D ; Absorptiometry, Photon ; Absorption ; Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Australia ; Biological and medical sciences ; Blood ; Bone Density ; Bone loss ; Bone turnover ; Bones ; Calcitriol ; Calcitriol - blood ; Calcium ; Calcium (urinary) ; Calcium - blood ; Calcium - pharmacokinetics ; Calcium - urine ; Calcium absorption ; Calcium phosphates ; Clinical Nutrition ; Comparative analysis ; Creatinine ; Creatinine - urine ; Cross-Sectional Studies ; Epidemiology ; Excretion ; Forearm ; Forearm - diagnostic imaging ; Humans ; Internal Medicine ; Intestinal Absorption ; Intestine ; Male ; Males ; Medical sciences ; Medicine ; Medicine & Public Health ; Men ; Metabolic Diseases ; Metals (hemochromatosis...) ; Middle Aged ; original-communication ; Other metabolic disorders ; Phosphates - urine ; Public Health ; Radionuclide Imaging ; Studies ; White people</subject><ispartof>European journal of clinical nutrition, 2004-02, Vol.58 (2), p.264-269</ispartof><rights>Springer Nature Limited 2004</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Macmillan Journals Ltd. Feb 2004</rights><rights>Nature Publishing Group 2004.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-e621c429b7ffc3a6b530378fd4870c437fd7b3fd12d34a55cb42080bad1824a83</citedby><cites>FETCH-LOGICAL-c581t-e621c429b7ffc3a6b530378fd4870c437fd7b3fd12d34a55cb42080bad1824a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15673967$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14749746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scopacasa, F</creatorcontrib><creatorcontrib>Wishart, J M</creatorcontrib><creatorcontrib>Horowitz, M</creatorcontrib><creatorcontrib>Morris, H A</creatorcontrib><creatorcontrib>Need, A G</creatorcontrib><title>Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Objective
: To obtain information on the causes of age-related bone loss in men and the concomitant decline in calcium absorption.
Design
: Cross-sectional study.
Setting
: Adelaide, South Australia, Australia.
Subjects
: A total of 95 healthy, Caucasian men (age range 27–87 y).
Results
: Calcium absorption declined with age (
r
=−0.46,
P
<0.0001), as did 24-h urine calcium, phosphate and creatinine (
r
>−0.21,
P
<0.05 for all); serum calcitriol and 25 hydroxyvitamin D did not change with age. Calcium absorption was related to serum calcitriol (
r
=0.20,
P
=0.05). An inverse relation between the residual deviations in calcium absorption, after allowing for its dependence on calcitriol, and age (
F
=5.4,
P
<0.005) was observed. The 24-h urinary calcium, phosphate and creatinine were all related to calcium absorption (
r
>0.41,
P
<0.0001). Forearm bone density fell with age (
r
=−0.45,
P
<0.0001) but was not related to calcium absorption, or markers of bone turnover.
Conclusions
: In healthy Caucasian males (i) calcium absorption falls, but serum calcitriol does not change with age, (ii) the relation between calcium absorption and serum calcitriol changes with age, indicative of an intestinal resistance to calcitriol and (iii) calcium absorption is a significant determinant of 24-h urinary calcium excretion.</description><subject>25-Hydroxyvitamin D</subject><subject>Absorptiometry, Photon</subject><subject>Absorption</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Australia</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Bone Density</subject><subject>Bone loss</subject><subject>Bone turnover</subject><subject>Bones</subject><subject>Calcitriol</subject><subject>Calcitriol - blood</subject><subject>Calcium</subject><subject>Calcium (urinary)</subject><subject>Calcium - blood</subject><subject>Calcium - pharmacokinetics</subject><subject>Calcium - urine</subject><subject>Calcium absorption</subject><subject>Calcium phosphates</subject><subject>Clinical Nutrition</subject><subject>Comparative analysis</subject><subject>Creatinine</subject><subject>Creatinine - urine</subject><subject>Cross-Sectional Studies</subject><subject>Epidemiology</subject><subject>Excretion</subject><subject>Forearm</subject><subject>Forearm - diagnostic imaging</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Intestinal Absorption</subject><subject>Intestine</subject><subject>Male</subject><subject>Males</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Men</subject><subject>Metabolic Diseases</subject><subject>Metals (hemochromatosis...)</subject><subject>Middle Aged</subject><subject>original-communication</subject><subject>Other metabolic disorders</subject><subject>Phosphates - urine</subject><subject>Public Health</subject><subject>Radionuclide Imaging</subject><subject>Studies</subject><subject>White people</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp90ktv1DAQAOAIgehSOHMCRUUtp2zt-BluVVUeUiUkBOfIcSZbrxx7sR0Qd344TjfSFtSiHCx5vhnbmSmKlxitMSLyPG7XsNVujTnCQohHxQpTwSvGKXpcrFDDaEUQEkfFsxi3COWgqJ8WR3mljaB8Vfz-AlYl413ZQfoJ4EqtrDbTWKou-rC7DSnXlxFC3rwNpmC8LY0rnQ-jsuUI7l0JP0wPTkM5-FCqDVRhLgx9dgliMi7DANHEpGaV_J1az4sng7IRXizrcfHt_dXXy4_V9ecPny4vrivNJE4V8BprWjedGAZNFO8YQUTIoadSIE2JGHrRkaHHdU-oYkx3tEYSdarHsqZKkuPibF93F_z3Kd-qHU3UYK1y4KfYSoRriuUM3_4XCkZlIzGnWb75R279FPJjY1tzWot8QY6zOnlQ4Ybn5hGWUbVHG2WhNW7wKSi9AQdBWe9gMHn7AjdMMNzUdfbre3z-ehiNvjfh7E7CDSibbqK309zj-Dc830MdfIwBhnYXzKjCrxajdp67Nm7bee7aZe5yxuvlgVM3Qn_wy6BlcLoAFXPjh5CnwMSDY1yQhs-F0N7FHHIbCIc_9fDZr_YpTqUpwKHmEv8D9x_6mw</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Scopacasa, F</creator><creator>Wishart, J M</creator><creator>Horowitz, M</creator><creator>Morris, H A</creator><creator>Need, A G</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol</title><author>Scopacasa, F ; Wishart, J M ; Horowitz, M ; Morris, H A ; Need, A G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-e621c429b7ffc3a6b530378fd4870c437fd7b3fd12d34a55cb42080bad1824a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Absorptiometry, Photon</topic><topic>Absorption</topic><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Australia</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Bone Density</topic><topic>Bone loss</topic><topic>Bone turnover</topic><topic>Bones</topic><topic>Calcitriol</topic><topic>Calcitriol - blood</topic><topic>Calcium</topic><topic>Calcium (urinary)</topic><topic>Calcium - blood</topic><topic>Calcium - pharmacokinetics</topic><topic>Calcium - urine</topic><topic>Calcium absorption</topic><topic>Calcium phosphates</topic><topic>Clinical Nutrition</topic><topic>Comparative analysis</topic><topic>Creatinine</topic><topic>Creatinine - urine</topic><topic>Cross-Sectional Studies</topic><topic>Epidemiology</topic><topic>Excretion</topic><topic>Forearm</topic><topic>Forearm - diagnostic imaging</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Intestinal Absorption</topic><topic>Intestine</topic><topic>Male</topic><topic>Males</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Men</topic><topic>Metabolic Diseases</topic><topic>Metals (hemochromatosis...)</topic><topic>Middle Aged</topic><topic>original-communication</topic><topic>Other metabolic disorders</topic><topic>Phosphates - urine</topic><topic>Public Health</topic><topic>Radionuclide Imaging</topic><topic>Studies</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scopacasa, F</creatorcontrib><creatorcontrib>Wishart, J M</creatorcontrib><creatorcontrib>Horowitz, M</creatorcontrib><creatorcontrib>Morris, H A</creatorcontrib><creatorcontrib>Need, A G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (ProQuest Medical & Health Databases)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest_Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scopacasa, F</au><au>Wishart, J M</au><au>Horowitz, M</au><au>Morris, H A</au><au>Need, A G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>58</volume><issue>2</issue><spage>264</spage><epage>269</epage><pages>264-269</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Objective
: To obtain information on the causes of age-related bone loss in men and the concomitant decline in calcium absorption.
Design
: Cross-sectional study.
Setting
: Adelaide, South Australia, Australia.
Subjects
: A total of 95 healthy, Caucasian men (age range 27–87 y).
Results
: Calcium absorption declined with age (
r
=−0.46,
P
<0.0001), as did 24-h urine calcium, phosphate and creatinine (
r
>−0.21,
P
<0.05 for all); serum calcitriol and 25 hydroxyvitamin D did not change with age. Calcium absorption was related to serum calcitriol (
r
=0.20,
P
=0.05). An inverse relation between the residual deviations in calcium absorption, after allowing for its dependence on calcitriol, and age (
F
=5.4,
P
<0.005) was observed. The 24-h urinary calcium, phosphate and creatinine were all related to calcium absorption (
r
>0.41,
P
<0.0001). Forearm bone density fell with age (
r
=−0.45,
P
<0.0001) but was not related to calcium absorption, or markers of bone turnover.
Conclusions
: In healthy Caucasian males (i) calcium absorption falls, but serum calcitriol does not change with age, (ii) the relation between calcium absorption and serum calcitriol changes with age, indicative of an intestinal resistance to calcitriol and (iii) calcium absorption is a significant determinant of 24-h urinary calcium excretion.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14749746</pmid><doi>10.1038/sj.ejcn.1601777</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2004-02, Vol.58 (2), p.264-269 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80124188 |
| source | EZB Electronic Journals Library |
| subjects | 25-Hydroxyvitamin D Absorptiometry, Photon Absorption Adult Age Age Factors Aged Aged, 80 and over Australia Biological and medical sciences Blood Bone Density Bone loss Bone turnover Bones Calcitriol Calcitriol - blood Calcium Calcium (urinary) Calcium - blood Calcium - pharmacokinetics Calcium - urine Calcium absorption Calcium phosphates Clinical Nutrition Comparative analysis Creatinine Creatinine - urine Cross-Sectional Studies Epidemiology Excretion Forearm Forearm - diagnostic imaging Humans Internal Medicine Intestinal Absorption Intestine Male Males Medical sciences Medicine Medicine & Public Health Men Metabolic Diseases Metals (hemochromatosis...) Middle Aged original-communication Other metabolic disorders Phosphates - urine Public Health Radionuclide Imaging Studies White people |
| title | Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol |
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