Treatment of Marburg Variant Multiple Sclerosis with Mitoxantrone

ABSTRACT Marburg variant multiple sclerosis (MS) is a severe, sometimes monophasic, form of MS leading to advanced disability or death within a period of weeks to months. No consistently successful treatment for Marburg variant MS has been described. The case reported here is that of a 34‐year‐old w...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroimaging 2004-01, Vol.14 (1), p.58-62
Main Authors: Jeffery, Douglas R., Lefkowitz, David S., Crittenden, Jeffrey P.
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - therapeutic use
Brain - pathology
Female
Humans
Magnetic Resonance Imaging
Marburg MS
mitoxantrone
Mitoxantrone - therapeutic use
MRI
Multiple Sclerosis - drug therapy
Multiple Sclerosis - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Marburg variant multiple sclerosis (MS) is a severe, sometimes monophasic, form of MS leading to advanced disability or death within a period of weeks to months. No consistently successful treatment for Marburg variant MS has been described. The case reported here is that of a 34‐year‐old woman with Marburg variant MS whose magnetic resonance imaging scan showed extensive brainstem, periventricular white matter, subcortical, and cortical involvement, giving the appearance of an “MS cerebritis.” The patient had no response to treatment with methylprednisolone but improved and recovered after treatment with mitoxantrone (MITX). Because MITX has potent anti‐inflammatory effects and demonstrated efficacy in worsening MS, it may be an appropriate agent for the treatment of Marburg variant MS.
ISSN:1051-2284
1552-6569
DOI:10.1111/j.1552-6569.2004.tb00217.x