Schizophrenia: Etiology and course

Decades of research on schizophrenia have not produced major breakthroughs, but gradual progress has been made in identifying risk factors and clarifying the nature of the etiologic process. This article provides an overview of trends in research findings as well as current assumptions about the int...

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Bibliographic Details
Published in:Annual review of psychology 2004-01, Vol.55 (1), p.401-430
Main Authors: WALKER, Elaine, KESTLER, Lisa, BOLLINI, Annie, HOCHMAN, Karen M
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Biological and medical sciences
Brain - abnormalities
Brain - metabolism
Brain - physiopathology
Care and treatment
Causes of
Cognition Disorders - etiology
Disease Progression
Dopamine - metabolism
Genetic aspects
Humans
Life Change Events
Medical research
Medical sciences
Psychiatry
Psychological research
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Risk factors
Schizophrenia
Schizophrenia - complications
Schizophrenia - etiology
Schizophrenia - physiopathology
Social aspects
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Summary:Decades of research on schizophrenia have not produced major breakthroughs, but gradual progress has been made in identifying risk factors and clarifying the nature of the etiologic process. This article provides an overview of trends in research findings as well as current assumptions about the interplay between environmental and genetic factors in the etiology of schizophrenia. Based on the cumulative findings, it appears that both genetic and prenatal factors can give rise to constitutional vulnerability. Subsequent neuromaturational processes, especially those that occur during adolescence, and exposure to stressful events can trigger the behavioral expression of this vulnerability.
ISSN:0066-4308
1545-2085
DOI:10.1146/annurev.psych.55.090902.141950