Annotating the Plasmodium genome and the enigma of the shikimate pathway

The completion of the Plasmodium falciparum genome sequence heralds a new era in the effort to identify all the parasite's genes along with their cellular functions. A combination of bioinformatics and experimental proof will facilitate this process. Many enzymes in metabolic processes have bee...

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Bibliographic Details
Published in:Trends in parasitology 2004-02, Vol.20 (2), p.60-65
Main Authors: McConkey, Glenn A., Pinney, John W., Westhead, David R., Plueckhahn, Kirsten, Fitzpatrick, Teresa B., Macheroux, Peter, Kappes, Barbara
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Biological and medical sciences
Computational Biology
Cytogenetics
Folic Acid - metabolism
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Genetics of eukaryotes. Biological and molecular evolution
Genome, Protozoan
Invertebrates
Models, Biological
Phosphotransferases (Alcohol Group Acceptor) - chemistry
Phosphotransferases (Alcohol Group Acceptor) - metabolism
Plasmodium falciparum
Plasmodium falciparum - enzymology
Plasmodium falciparum - genetics
Plasmodium falciparum - metabolism
Protozoa
Sequence Alignment
Shikimic Acid - metabolism
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Summary:The completion of the Plasmodium falciparum genome sequence heralds a new era in the effort to identify all the parasite's genes along with their cellular functions. A combination of bioinformatics and experimental proof will facilitate this process. Many enzymes in metabolic processes have been identified, but several examples exist of incomplete pathways, such as the shikimate pathway. This review uses the example of the shikimate pathway to examine the application of bioinformatics to lead experimental design in post-genomic biology.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2003.11.001