Direct Electrophilic Silylation of Terminal Alkynes

A variety of alkynylsilanes were efficiently prepared via direct silylation of terminal alkynes with aminosilanes in the presence of zinc halides. Base- and nucleophile-sensitive functionalities were perfectly tolerated under the above reaction conditions. Initial mechanistic studies support the ele...

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Bibliographic Details
Published in:Organic letters 2004-02, Vol.6 (3), p.421-424
Main Authors: Andreev, Aleksey A, Konshin, Valeri V, Komarov, Nikolai V, Rubin, Michael, Brouwer, Chad, Gevorgyan, Vladimir
Format: Article
Language:English
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Summary:A variety of alkynylsilanes were efficiently prepared via direct silylation of terminal alkynes with aminosilanes in the presence of zinc halides. Base- and nucleophile-sensitive functionalities were perfectly tolerated under the above reaction conditions. Initial mechanistic studies support the electrophilic character of this transformation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol036328p