Low-grade myofibroblastic sarcoma of the vulva

Background. Vulvar sarcomas are rare tumors. A distinctive low-grade myofibroblastic sarcoma is described. Case. A 46-year-old female presented with a progressively enlarging vulvar mass. Pathological evaluation revealed a low-grade myofibroblastic sarcoma. The immunophenotype is outlined and ultras...

Full description

Saved in:
Bibliographic Details
Published in:Gynecologic oncology 2004, Vol.92 (1), p.361-364
Main Authors: Roth, Ted M, Fratkin, Jonathan, Woodring, T.Casey, McGehee, Ramon P
Format: Article
Language:English
Subjects:
Female
Humans
Immunohistochemistry
Middle Aged
Myosarcoma - metabolism
Myosarcoma - pathology
Receptors, Steroid - biosynthesis
Sarcoma
Tumor
Tumor Suppressor Protein p53 - biosynthesis
Vulva
Vulvar Neoplasms - metabolism
Vulvar Neoplasms - pathology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Vulvar sarcomas are rare tumors. A distinctive low-grade myofibroblastic sarcoma is described. Case. A 46-year-old female presented with a progressively enlarging vulvar mass. Pathological evaluation revealed a low-grade myofibroblastic sarcoma. The immunophenotype is outlined and ultrastructural features are highlighted. Tumor cells were positive for p53 protein, smooth muscle actin, steroid receptors, and showed myofibroblastic differentiation on electron microscopy. The patient has been followed for >14 months without evidence of recurrence. Conclusion. The tumor was positive for p53, mitotically active, but was categorized as a low-grade malignancy. Immunohistochemical and ultrastructural criteria were utilized to distinguish this tumor from other neoplasms.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2003.09.035