Chronic antidepressants reverse cerebrocortical allopregnanolone decline in the olfactory-bulbectomized rat

Olfactory bulbectomy is one of the most validated models of depression. We demonstrate that bilateral removal of the olfactory bulbs in rats produced a significant decline of allopregnanolone content in a select cerebrocortical area which was reversed by chronic (3-week) treatment with three differe...

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Bibliographic Details
Published in:European journal of pharmacology 2004-02, Vol.486 (1), p.31-34
Main Authors: Uzunova, Veska, Wrynn, Aileen S., Kinnunen, Anu, Ceci, Melanie, Kohler, Christian, Uzunov, Doncho P.
Format: Article
Language:English
Subjects:
Allopregnanolone
Animals
Antidepressant
Antidepressive Agents - administration & dosage
Biological and medical sciences
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Male
Medical sciences
Olfactory Bulb - drug effects
Olfactory Bulb - metabolism
Olfactory Bulb - surgery
Olfactory-bulbectomized rat
Pharmacology. Drug treatments
Pregnanolone - metabolism
Rats
Rats, Sprague-Dawley
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Summary:Olfactory bulbectomy is one of the most validated models of depression. We demonstrate that bilateral removal of the olfactory bulbs in rats produced a significant decline of allopregnanolone content in a select cerebrocortical area which was reversed by chronic (3-week) treatment with three different classes of antidepressant (desipramine, fluoxetine, and sertraline, and venlafaxine). The effects of the chronic antidepressant treatments on allopregnanolone cortical content are observed at a time which typically coincides with the drug's abilities to reverse the behavioral deficits of the bulbectomy syndrome. We therefore propose that normalization of allopregnanolone cerebrocortical levels may contribute to the antidepressant-like profile of these drugs in the olfactory-bulbectomized rat model of depression.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2003.12.002