Etiopathogenesis of cholesteatoma

Cholesteatoma is a destructive lesion of the temporal bone that gradually expands and causes complications by erosion of the adjacent bony structures. Bone resorption can result in destruction of the ossicular chain and otic capsule with consecutive hearing loss, vestibular dysfunction, facial paral...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2004, Vol.261 (1), p.6-24
Main Authors: OLSZEWSKA, Ewa, WAGNER, Mathias, BERNAL-SPREKELSEN, Manuel, EBMEYER, Jörg, DAZERT, Stefan, HILDMANN, Henning, SUDHOFF, Holger
Format: Article
Language:English
Subjects:
Antigens, Differentiation - genetics
Apoptosis
Biological and medical sciences
Bone Resorption
Cell Cycle
Cholesteatoma, Middle Ear - classification
Cholesteatoma, Middle Ear - epidemiology
Cholesteatoma, Middle Ear - etiology
Cholesteatoma, Middle Ear - pathology
Cytokines - metabolism
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Extracellular Matrix - genetics
Extracellular Matrix - metabolism
Growth Substances - genetics
Humans
Lipid Metabolism
Medical sciences
Models, Biological
Neovascularization, Physiologic - physiology
Otorhinolaryngology. Stomatology
Transcription Factors - genetics
Tumors
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Summary:Cholesteatoma is a destructive lesion of the temporal bone that gradually expands and causes complications by erosion of the adjacent bony structures. Bone resorption can result in destruction of the ossicular chain and otic capsule with consecutive hearing loss, vestibular dysfunction, facial paralysis and intracranial complications. Surgery is the only treatment of choice. The etiopathogenesis of cholesteatoma, however, is still controversial. This review was designed to understand the reasons for these disparities and to reduce or eliminate them. Future studies focused on developmental, epidemiological, hormonal and genetic factors as well as on treatment are likely to contribute to further understanding of cholesteatoma pathogenesis.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-003-0623-x