Immune responses to influenza immunization in children receiving maintenance chemotherapy for acute lymphoblastic leukemia

Purpose To compare the immune responses to influenza vaccine in children with acute lymphoblastic leukemia (ALL) receiving maintenance chemotherapy with those in healthy children. Methods Hemagglutinin‐inhibition (HAI) antibody titers were determined before and after influenza vaccination in childre...

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Bibliographic Details
Published in:Pediatric Blood & Cancer 2004-01, Vol.42 (1), p.36-40
Main Authors: Porter, Christopher C., Edwards, Kathryn M., Zhu, Yuwei, Frangoul, Haydar
Format: Article
Language:English
Subjects:
acute lymphoblastic leukemia
Antibodies, Viral - analysis
Antigens, Viral - immunology
Antigens, Viral - metabolism
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Case-Control Studies
Child
Female
Hemagglutination Inhibition Tests
Hematologic and hematopoietic diseases
Humans
immune responses
Immunization
Influenza B virus - immunology
influenza vaccine
Influenza Vaccines - immunology
Influenza Vaccines - therapeutic use
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
Serologic Tests
Vaccination
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Summary:Purpose To compare the immune responses to influenza vaccine in children with acute lymphoblastic leukemia (ALL) receiving maintenance chemotherapy with those in healthy children. Methods Hemagglutinin‐inhibition (HAI) antibody titers were determined before and after influenza vaccination in children with ALL and healthy controls. Immune responses were measured as geometric mean titers (GMT) and 4‐fold rises in HAI titers. Results Although post‐immunization GMT were lower in children with ALL compared to healthy children for the H1N1 antigen (P 
ISSN:1545-5009
1545-5017
1096-911X
DOI:10.1002/pbc.10459