Transverse myelitis as the first manifestation of systemic lupus erythematosus or lupus-like disease good functional outcome and relevance of antiphospholipid antibodies

• Published in: Journal of rheumatology 2004-02, Vol.31 (2), p.280-285
• Main Authors: D'CRUZ, David P, MELLOR-PITA, Susana, JOVEN, Beatriz, SANNA, Giovanni, ALLANSON, Judith, TAYLOR, James, KHAMASHTA, Munther A, HUGHES, Graham R. V
• Format: Article
• Language: English
• Subjects: Adult; Age of Onset; Aged; Antibodies, Antiphospholipid - blood; Biological and medical sciences; Diseases of the osteoarticular system; Female; Humans; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - immunology; Magnetic Resonance Imaging; Medical sciences; Middle Aged; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Myelitis, Transverse - diagnosis; Myelitis, Transverse - etiology; Myelitis, Transverse - immunology; Neurology
• ISSN: 0315-162X; 1499-2752

Transverse myelitis (TM) is a rare complication of systemic lupus erythematosus (SLE). Although usually a late manifestation of SLE, it can occur at presentation. We investigated the clinical presentation, treatment and outcome of 15 patients with TM as the presenting manifestation of SLE or lupus-like disease. All patients received corticosteroids, while 13 also received immunosuppressive therapy. Five patients were fully anticoagulated with warfarin. A sensory level with spastic lower limb weakness and sphincter disturbance was the most common presentation: 14/15 patients had a thoracic or cervical sensory level. Cerebrospinal fluid examination showed high protein concentrations in 3 patients and oligoclonal bands in 8. Eleven of the 15 (73%) had antiphospholipid antibodies (aPL). Of the 15 patients, 3 had complete resolution of the symptoms, 6 had good functional improvements, 5 had good to fair outcome with some functional deficit, and one patient who received corticosteroids alone later died from pneumonia. We describe 15 patients with TM as the presenting manifestation of SLE or lupus-like disease with a high prevalence of aPL. Our data support the view that early diagnosis and immunosuppressive therapy may be superior to corticosteroids alone in improving functional outcome. In those patients with aPL, antiplatelet agents and/or warfarin should also be considered.