Homology between feline herpesvirus-1 and canine herpesvirus

The purpose of this study was to determine the extent of the relatedness between feline herpesvirus-1 (FHV-1) and canine herpesvirus (CHV). Immunoprecipitation studies using antisera to FHV-1 and CHV revealed that both share virion glycoprotein antigens with apparent molecular weights of approximate...

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Bibliographic Details
Published in:Archives of virology 1990-01, Vol.115 (1/2), p.139-145
Main Authors: Rota, P.A, Maes, R.K
Format: Article
Language:English
Subjects:
Animals
antigens
Antigens, Viral - analysis
Antigens, Viral - immunology
Biological and medical sciences
Blotting, Southern
Canid herpesvirus 1
Cat Diseases - microbiology
Cats
characterization
cross reaction
Cross Reactions
DNA, Viral - analysis
Dog Diseases - microbiology
Dogs
Electrophoresis, Polyacrylamide Gel
Felid herpesvirus 1
Fundamental and applied biological sciences. Psychology
genome
Herpesviridae - genetics
Herpesviridae - immunology
Herpesviridae Infections - microbiology
Herpesviridae Infections - veterinary
Herpesvirus 1, Canid - genetics
Herpesvirus 1, Canid - immunology
Microbiology
Morphology, structure, chemical composition, physicochemical properties
Nucleic Acid Hybridization
nucleotide sequences
polyacrylamide gel electrophoresis
precipitin tests
Restriction Mapping
Sequence Homology, Nucleic Acid
Southern blotting
Virology
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Summary:The purpose of this study was to determine the extent of the relatedness between feline herpesvirus-1 (FHV-1) and canine herpesvirus (CHV). Immunoprecipitation studies using antisera to FHV-1 and CHV revealed that both share virion glycoprotein antigens with apparent molecular weights of approximately 60 and 68 kDa. Two non-glycosylated, virion-associated antigens of each virus also displayed weaker cross reactivity. Southern blot hybridization experiments indicated that restriction fragments which represented approximately 51% of the FHV-1 genome hybridized to CHV DNA under conditions which allowed less than 7% base pair mismatch. This is the first molecular characterization of cross-reactivity between FHV-1 and another herpesvirus.
ISSN:0304-8608
1432-8798
DOI:10.1007/BF01310631