Applicability of discovery science approach to determine biological effects of mobile phone radiation

We argue that the use of high‐throughput screening techniques, although expensive and laborious, is justified and necessary in studies that examine biological effects of mobile phone radiation. The “case of hsp27 protein” presented here suggests that even proteins with only modestly altered (by expo...

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Bibliographic Details
Published in:Proteomics (Weinheim) 2004-02, Vol.4 (2), p.426-431
Main Authors: Leszczynski, Dariusz, Nylund, Reetta, Joenväärä, Sakari, Reivinen, Jukka
Format: Article
Language:English
Subjects:
Cell Phone
Cells, Cultured
Cytoskeletal Proteins - analysis
Cytoskeletal Proteins - metabolism
Cytoskeleton - drug effects
Cytoskeleton - metabolism
Cytoskeleton - radiation effects
Electromagnetic Fields - adverse effects
Electrophoresis, Gel, Two-Dimensional
Endothelial Cells - drug effects
Endothelial Cells - metabolism
Endothelial Cells - radiation effects
Enzyme Inhibitors - pharmacology
Gene expression
Heat-Shock Proteins - analysis
Heat-Shock Proteins - metabolism
hsp 27
HSP27 Heat-Shock Proteins
Humans
Imidazoles - pharmacology
MAP Kinase Signaling System - drug effects
MAP Kinase Signaling System - radiation effects
Microscopy, Fluorescence
Mitogen-Activated Protein Kinases - antagonists & inhibitors
Mitogen-Activated Protein Kinases - metabolism
Mobile phone radiation
Neoplasm Proteins - analysis
Neoplasm Proteins - metabolism
p38 Mitogen-Activated Protein Kinases
Protein expression
Pyridines - pharmacology
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Summary:We argue that the use of high‐throughput screening techniques, although expensive and laborious, is justified and necessary in studies that examine biological effects of mobile phone radiation. The “case of hsp27 protein” presented here suggests that even proteins with only modestly altered (by exposure to mobile phone radiation) expression and activity might have an impact on cell physiology. However, this short communication does not attempt to present the full scientific evidence that is far too large to be presented in a single article and that is being prepared for publication in three separate research articles. Examples of the experimental evidence presented here were designed to show the flow of experimental process demonstrating that the use of high‐throughput screening techniques might help in rapid identification of the responding proteins. This, in turn, can help in speeding up of the process of determining whether these changes might affect human health.*
ISSN:1615-9853
1615-9861
DOI:10.1002/pmic.200300646