Prostaglandins Contribute to Activation of Baroreceptors in Rabbits: Possible Paracrine Influence of Endothelium

The purpose of this study was to test the hypothesis that prostaglandins released from vascular endothelial cells contribute to activation of baroreceptors during increases in arterial pressure. Baroreceptor activity was recorded from the vascularly isolated carotid sinus in rabbits anesthetized wit...

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Bibliographic Details
Published in:Circulation research 1990-12, Vol.67 (6), p.1394-1404
Main Authors: Chen, Hsing I, Chapleau, Mark W, McDowell, Thomas S, Abboud, Francois M
Format: Article
Language:English
Subjects:
Animals
Aspirin - pharmacology
Biological and medical sciences
Blood vessels and receptors
Carotid Sinus - physiology
Endothelium, Vascular - physiology
Epoprostenol - pharmacology
Fundamental and applied biological sciences. Psychology
Indomethacin - pharmacology
Male
Microscopy, Electron, Scanning
Pressoreceptors - drug effects
Pressoreceptors - physiology
Prostaglandins - physiology
Rabbits
Vertebrates: cardiovascular system
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Summary:The purpose of this study was to test the hypothesis that prostaglandins released from vascular endothelial cells contribute to activation of baroreceptors during increases in arterial pressure. Baroreceptor activity was recorded from the vascularly isolated carotid sinus in rabbits anesthetized with chloralose. Baroreceptor activity was measured during ramp or step increases in nonpulsatile carotid sinus pressure over a range of 0–175 mm Hg. Exposure of the isolated carotid sinus to inhibitors of prostaglandin formation (indomethacin [n = 10] or aspirin [n=6]) decreased baroreceptor activity significantly (p
ISSN:0009-7330
1524-4571
DOI:10.1161/01.res.67.6.1394