The Effect of Highly Active Antiretroviral Therapy on Dermatologic Disease in a Longitudinal Study of HIV Type 1-Infected Women

The effect of highly active antiretroviral therapy (HAART) on skin diseases was evaluated in 878 human immunodeficiency virus type 1 (HIV-1)-infected women in the Women's Interagency HIV Study, a multicenter prospective study. HIV-1-infected women receiving HAART were less likely to have eczema...

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Bibliographic Details
Published in:Clinical infectious diseases 2004-02, Vol.38 (4), p.579-584
Main Authors: Maurer, Toby, Rodrigues, Lori K. E., Ameli, Niloufar, Phanuphak, Nittaya, Gange, Stephen J., DeHovitz, Jack, French, Audrey L., Glesby, Marshall, Jordan, Carol, Khalsa, Ann, Hessol, Nancy A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active
Antiviral agents
Biological and medical sciences
CD4 Lymphocyte Count
Dermatology
Dermatomycoses - complications
Dermatomycoses - epidemiology
Dermatomycoses - immunology
Dermatomycoses - microbiology
Eczema
Eczema - epidemiology
Epidemiology
Female
Highly active antiretroviral therapy
HIV
HIV 1
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HIV/AIDS
Human immunodeficiency virus 1
Human viral diseases
Humans
Infections
Infectious diseases
Longitudinal Studies
Medical sciences
Middle Aged
Nadir
Onychomycosis - epidemiology
Pharmacology. Drug treatments
Prevalence
Prospective Studies
Skin diseases
Tinea Pedis - epidemiology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Women's Health
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Summary:The effect of highly active antiretroviral therapy (HAART) on skin diseases was evaluated in 878 human immunodeficiency virus type 1 (HIV-1)-infected women in the Women's Interagency HIV Study, a multicenter prospective study. HIV-1-infected women receiving HAART were less likely to have eczema, folliculitis, tinea pedis, and xerosis than were women who had not initiated HAART, independent of CD4+ cell count. Participants who had a prior history of a nadir CD4+ cell count of 200 cells/µL and recent CD4+ cell counts of >349 cells/µL. An HIV-1 RNA load of >100,000 copies/mL was associated with increased prevalence of herpes zoster infection (odds ratio, 6.10; 95% confidence interval, 2.00–18.65). History of injection drug use was associated with a higher prevalence of onychomycosis, tinea pedis, and xerosis. Molluscum contagiosum was more prevalent among younger women.
ISSN:1058-4838
1537-6591
DOI:10.1086/381264