Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses

Dendritic cells (DCs) play a central role in initiating immune responses. Despite this, there is little understanding how different DC subsets contribute to immunity to different pathogens. CD8alpha(+) DC have been shown to prime immunity to HSV. Whether this very limited capacity of a single DC sub...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2004-02, Vol.172 (4), p.1996-2000
Main Authors: Belz, Gabrielle T, Smith, Christopher M, Eichner, Daniel, Shortman, Ken, Karupiah, Guna, Carbone, Francis R, Heath, William R
Format: Article
Language:English
Subjects:
Animals
CD8 Antigens - biosynthesis
Cell Division - immunology
Cell Separation
Dendritic Cells - immunology
Dendritic Cells - metabolism
Dendritic Cells - virology
Herpes Simplex - immunology
Immunity, Cellular
Injections, Intravenous
Injections, Subcutaneous
Interphase - immunology
Lymph Nodes - cytology
Lymph Nodes - immunology
Lymph Nodes - virology
Lymphocyte Activation - immunology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Orthomyxoviridae Infections - immunology
Spleen - cytology
Spleen - immunology
Spleen - virology
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Cytotoxic - virology
Vaccinia - immunology
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Summary:Dendritic cells (DCs) play a central role in initiating immune responses. Despite this, there is little understanding how different DC subsets contribute to immunity to different pathogens. CD8alpha(+) DC have been shown to prime immunity to HSV. Whether this very limited capacity of a single DC subset priming CTL immunity is restricted to HSV infection or is a more general property of anti-viral immunity was examined. Here, we show that the CD8alpha(+) DCs are the principal DC subset that initiates CTL immunity to s.c. infection by influenza virus, HSV, and vaccinia virus. This same subset also dominated immunity after i.v. infection with all three viruses, suggesting a similar involvement in other routes of infection. These data highlight the general role played by CD8alpha(+) DCs in CTL priming to viral infection and raises the possibility that this DC subset is specialized for viral immunity.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.172.4.1996