Health-Related Quality of Life of Patients with HIV Disease: Impact of Hepatitis C Coinfection

Health-related quality of life (HRQOL) is diminished in patients infected with both hepatitis C virus (HCV) and human immunodeficiency virus (HIV), but the effect of HIV/HCV coinfection on HRQOL is unknown. We compared the HRQOL of urban HIV/HCV coinfected patients with that of patients infected wit...

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Bibliographic Details
Published in:Clinical infectious diseases 2004-02, Vol.38 (4), p.572-578
Main Authors: Fleming, Catherine A., Christiansen, Demian, Nunes, David, Heeren, Timothy, Thornton, David, Horsburgh, C. Robert, Koziel, Margaret James, Graham, Camilla, Craven, Donald E.
Format: Article
Language:English
Subjects:
Adult
AIDS
Biological and medical sciences
Coinfection
Depressive disorders
Female
Hepacivirus
Hepatitis C - complications
Hepatitis C - psychology
Hepatitis C virus
Highly active antiretroviral therapy
HIV
HIV Infections - complications
HIV Infections - psychology
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Infections
Infectious diseases
Injections
Male
Medical sciences
Middle Aged
Multivariate Analysis
Quality of Life
Questionnaires
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
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Summary:Health-related quality of life (HRQOL) is diminished in patients infected with both hepatitis C virus (HCV) and human immunodeficiency virus (HIV), but the effect of HIV/HCV coinfection on HRQOL is unknown. We compared the HRQOL of urban HIV/HCV coinfected patients with that of patients infected with either HCV or HIV alone. We then compared the 3 groups with a US population sample, adjusting for demographic characteristics. HRQOL for the group of HIV/HCV coinfected patients was statistically similar to that of HRQOL in patients with either HCV or HIV alone, but the 3 groups had a significantly decreased HRQOL than did the adjusted US population. Using multivariate techniques, we determined that age, unemployment, injection drug use, and depression were associated with impaired HRQOL. These findings underscore the importance of a multidisciplinary approach to the treatment of these patient populations.
ISSN:1058-4838
1537-6591
DOI:10.1086/381263