C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice

Plasma C-reactive protein (CRP) concentration is a strong predictor of atherosclerosis. However, to date, there is no in vivo evidence that CRP is proatherogenic. We studied the effect of human CRP transgene (tg) expression, under basal and turpentine-stimulated conditions, on atherosclerosis in apo...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-02, Vol.109 (5), p.647-655
Main Authors: PAUL, Antoni, KO, Kerry W. S, LI, Lan, YECHOOR, Vijay, MCCRORY, Mark A, SZALAI, Alexander J, CHAN, Lawrence
Format: Article
Language:English
Subjects:
Animals
Aorta - chemistry
Aorta - pathology
Apolipoproteins E - genetics
Arteriosclerosis - metabolism
Arteriosclerosis - pathology
Biological and medical sciences
Blood and lymphatic vessels
C-Reactive Protein - analysis
C-Reactive Protein - genetics
C-Reactive Protein - physiology
Cardiology. Vascular system
Complement C3 - analysis
Disease Progression
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Humans
Kinetics
Male
Medical sciences
Mice
Mice, Knockout
Mice, Transgenic
Nitric Oxide Synthase - metabolism
Nitric Oxide Synthase Type II
Nitric Oxide Synthase Type III
Phenotype
Receptor, Angiotensin, Type 1 - metabolism
Risk Factors
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Summary:Plasma C-reactive protein (CRP) concentration is a strong predictor of atherosclerosis. However, to date, there is no in vivo evidence that CRP is proatherogenic. We studied the effect of human CRP transgene (tg) expression, under basal and turpentine-stimulated conditions, on atherosclerosis in apolipoprotein (apo) E-/- mice. Aortic atherosclerotic lesions in 29-week-old male mice were 48% larger (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000114526.50618.24