Double‐blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24‐h oesophageal and intragastric pH in Chinese subjects with gastro‐oesophageal reflux disease

Summary Background : Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. Aim : To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24‐h oesophageal and intragastric pH profiles in Chinese patient...

Full description

Saved in:
Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2004-02, Vol.19 (4), p.455-462
Main Authors: Wong, W. M., Lai, K. C., Hui, W. M., Lam, K. F., Huang, J. Q., Hu, W. H. C., Wong, N. Y. H., Lam, C. L. K., Xia, H. H. X., Chan, A. O. O., Lam, S. K., Wong, B. C. Y.
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles
Anti-Ulcer Agents - administration & dosage
Biological and medical sciences
China - ethnology
Cross-Over Studies
Double-Blind Method
Female
Gastric Acidity Determination
Gastroesophageal Reflux - drug therapy
Gastroesophageal Reflux - ethnology
Humans
Hydrogen-Ion Concentration
Lansoprazole
Male
Medical sciences
Middle Aged
Omeprazole - administration & dosage
Omeprazole - analogs & derivatives
Pharmacology. Drug treatments
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background : Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. Aim : To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24‐h oesophageal and intragastric pH profiles in Chinese patients with gastro‐oesophageal reflux disease. Methods : Forty‐four patients (male to female ratio, 27 : 17; mean age, 53 years; 55% with oesophagitis) with gastro‐oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24‐h oesophageal and intragastric pH, gastro‐oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period. Results : Lansoprazole 30 mg maintained an intragastric pH > 4 for 10.5 h vs. 9.6 h for lansoprazole 15 mg (P = 0.44). The percentage total time at oesophageal pH 
ISSN:0269-2813
1365-2036
DOI:10.1046/j.1365-2036.2004.01846.x