Colloidal effect of albumin on the placental lactogen and chorionic gonadotrophin releases from human term placental explants

Albumin has been reported to stimulate the release of placental lactogen and chorionic gonadotrophin from human term placental explants within physiological concentrations. This study aimed at characterizing further its effect on the placental hormonal secretion. The placental lactogen and chorionic...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2004-03, Vol.315 (2), p.342-348
Main Authors: Lambot, N, Lebrun, P, Cirelli, N, Vanbellinghen, A.M, Delogne-Desnoeck, J, Graff, G, Meuris, S
Format: Article
Language:English
Subjects:
Albumin
Albumins - chemistry
Animals
Calcium
Calcium - chemistry
Calcium - metabolism
Cattle
Chorionic Gonadotropin - chemistry
Colloidal osmotic pressure
Colloids - chemistry
Dextrans - chemistry
Dose-Response Relationship, Drug
Human chorionic gonadotrophin
Human placental lactogen
Humans
Placenta
Placenta - metabolism
Placental Lactogen - chemistry
Serum Albumin - metabolism
Syncytiotrophoblast
Time Factors
Verapamil - chemistry
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Summary:Albumin has been reported to stimulate the release of placental lactogen and chorionic gonadotrophin from human term placental explants within physiological concentrations. This study aimed at characterizing further its effect on the placental hormonal secretion. The placental lactogen and chorionic gonadotrophin secretory response of incubated explants to 5% albumin was reproduced by colloidal agents, i.e., dextran (4.5%) and polygelin (4%), indicating that a rise in colloidal osmotic pressure can elicit hormonal release from the syncytiotrophoblast. Their secretory effects were not modified by the absence of extracellular calcium or the presence of verapamil in the medium. The three agents also provoked a marked increase in 45calcium outflow from preloaded and perifused explants that persisted in absence of extracellular calcium. These data indicate that the triggering effect of albumin on placental lactogen and chorionic gonadotrophin release can be partly reproduced by colloidal agents and is independent of extracellular calcium.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2004.01.062