Decreased CD4+CD25+ T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus

Recent animal studies have shown that CD4+CD25+ T cells play a crucial role in the suppression of the immune response and that depletion of this subset of T cells might lead to development of autoimmune diseases. The aim of the present study was to investigate the levels of CD4+CD25+ T cells in the...

Full description

Saved in:
Bibliographic Details
Published in:Scandinavian journal of immunology 2004-02, Vol.59 (2), p.198-202
Main Authors: Liu, M.‐F., Wang, C.‐R., Fung, L.‐L., Wu, C.‐R.
Format: Article
Language:English
Subjects:
CD4-Positive T-Lymphocytes - immunology
Female
Flow Cytometry
Humans
Leukocyte Count
Leukocytes, Mononuclear - immunology
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Male
Receptors, Interleukin-2 - blood
Receptors, Interleukin-2 - immunology
Statistics, Nonparametric
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent animal studies have shown that CD4+CD25+ T cells play a crucial role in the suppression of the immune response and that depletion of this subset of T cells might lead to development of autoimmune diseases. The aim of the present study was to investigate the levels of CD4+CD25+ T cells in the peripheral blood of patients with systemic lupus erythematosus (SLE). Ninety‐four SLE patients, 52 patients with rheumatoid arthritis (RA) and 50 age‐ and gender‐matched healthy individuals were enrolled in the study. A flowcytometric method was applied in the measurement of CD4+CD25+ T cells. The results showed that patients with SLE had statistically lower levels of CD4+CD25+ T cells than did normal controls, when expressed as either percentages of peripheral blood mononuclear cells (PBMCs) (mean ± SD, 8.49 ± 6.36 versus 11.11 ± 4.58%, P 
ISSN:0300-9475
1365-3083
DOI:10.1111/j.0300-9475.2004.01370.x