Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and concentration of selenium

Background: The effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) was monitored on the speed of attaining euthyroidism in a group of patients with Graves' disease, treated with methimazole. Methods: The activity of glutathione pero...

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Bibliographic Details
Published in:Clinica chimica acta 2004-03, Vol.341 (1), p.55-63
Main Authors: Vrca, Vesna Bacic, Skreb, Franjo, Cepelak, Ivana, Romic, Zeljko, Mayer, Ljiljana
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Antioxidants - metabolism
Antioxidants - therapeutic use
Antithyroid Agents - therapeutic use
Drug Therapy, Combination
Female
Glutathione peroxidase
Glutathione Peroxidase - blood
Graves Disease - drug therapy
Graves' disease
Hemoglobins - metabolism
Humans
Male
Methimazole - therapeutic use
Selenium
Selenium - blood
Spectrophotometry, Atomic
Thyrotropin - blood
Thyroxine - blood
Triiodothyronine - blood
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Summary:Background: The effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) was monitored on the speed of attaining euthyroidism in a group of patients with Graves' disease, treated with methimazole. Methods: The activity of glutathione peroxidase in whole blood and the concentrations of selenium, pituitary and thyroid hormones in serum were measured, prior to commencement of therapy and after 30 and 60 days. Results: Patients who received supplementation with antioxidants in addition to therapy with methimazole (Group A, n=29) attained euthyroidism faster than the patients treated with only methimazole (Group B, n=28). The concentration of selenium in the serum of patients in Group A increased significantly during treatment ( p
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cccn.2003.10.028