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Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and concentration of selenium
Background: The effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) was monitored on the speed of attaining euthyroidism in a group of patients with Graves' disease, treated with methimazole. Methods: The activity of glutathione pero...
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| Published in: | Clinica chimica acta 2004-03, Vol.341 (1), p.55-63 |
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| container_end_page | 63 |
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| container_title | Clinica chimica acta |
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| creator | Vrca, Vesna Bacic Skreb, Franjo Cepelak, Ivana Romic, Zeljko Mayer, Ljiljana |
| description | Background: The effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) was monitored on the speed of attaining euthyroidism in a group of patients with Graves' disease, treated with methimazole.
Methods: The activity of glutathione peroxidase in whole blood and the concentrations of selenium, pituitary and thyroid hormones in serum were measured, prior to commencement of therapy and after 30 and 60 days.
Results: Patients who received supplementation with antioxidants in addition to therapy with methimazole (Group A,
n=29) attained euthyroidism faster than the patients treated with only methimazole (Group B,
n=28). The concentration of selenium in the serum of patients in Group A increased significantly during treatment (
p |
| doi_str_mv | 10.1016/j.cccn.2003.10.028 |
| format | article |
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Methods: The activity of glutathione peroxidase in whole blood and the concentrations of selenium, pituitary and thyroid hormones in serum were measured, prior to commencement of therapy and after 30 and 60 days.
Results: Patients who received supplementation with antioxidants in addition to therapy with methimazole (Group A,
n=29) attained euthyroidism faster than the patients treated with only methimazole (Group B,
n=28). The concentration of selenium in the serum of patients in Group A increased significantly during treatment (
p<0.001), while there was no statistically significant change in the patients in Group B. The concentration of selenium in the serum between the groups differed statistically significantly 30 days (
p<0.05) and 60 days (
p<0.01) after the commencement of therapy. Activity of glutathione peroxidase in whole blood increased during treatment in both groups of patients. However, a statistically more significant increase occurred in Group A compared to Group B, 30 days after the commencement of therapy (
p<0.01).
Conclusion: The results of the study clearly indicate that supplementation with antioxidants in the treatment of Graves' disease is justified, particularly those containing selenium.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cccn.2003.10.028</identifier><identifier>PMID: 14967159</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Antioxidants ; Antioxidants - metabolism ; Antioxidants - therapeutic use ; Antithyroid Agents - therapeutic use ; Drug Therapy, Combination ; Female ; Glutathione peroxidase ; Glutathione Peroxidase - blood ; Graves Disease - drug therapy ; Graves' disease ; Hemoglobins - metabolism ; Humans ; Male ; Methimazole - therapeutic use ; Selenium ; Selenium - blood ; Spectrophotometry, Atomic ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>Clinica chimica acta, 2004-03, Vol.341 (1), p.55-63</ispartof><rights>2004 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-37c523e11e326def46bdecc5835014e99978abc1641e66b4f3ed7792a51a2f753</citedby><cites>FETCH-LOGICAL-c352t-37c523e11e326def46bdecc5835014e99978abc1641e66b4f3ed7792a51a2f753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14967159$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vrca, Vesna Bacic</creatorcontrib><creatorcontrib>Skreb, Franjo</creatorcontrib><creatorcontrib>Cepelak, Ivana</creatorcontrib><creatorcontrib>Romic, Zeljko</creatorcontrib><creatorcontrib>Mayer, Ljiljana</creatorcontrib><title>Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and concentration of selenium</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Background: The effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) was monitored on the speed of attaining euthyroidism in a group of patients with Graves' disease, treated with methimazole.
Methods: The activity of glutathione peroxidase in whole blood and the concentrations of selenium, pituitary and thyroid hormones in serum were measured, prior to commencement of therapy and after 30 and 60 days.
Results: Patients who received supplementation with antioxidants in addition to therapy with methimazole (Group A,
n=29) attained euthyroidism faster than the patients treated with only methimazole (Group B,
n=28). The concentration of selenium in the serum of patients in Group A increased significantly during treatment (
p<0.001), while there was no statistically significant change in the patients in Group B. The concentration of selenium in the serum between the groups differed statistically significantly 30 days (
p<0.05) and 60 days (
p<0.01) after the commencement of therapy. Activity of glutathione peroxidase in whole blood increased during treatment in both groups of patients. However, a statistically more significant increase occurred in Group A compared to Group B, 30 days after the commencement of therapy (
p<0.01).
Conclusion: The results of the study clearly indicate that supplementation with antioxidants in the treatment of Graves' disease is justified, particularly those containing selenium.</description><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - therapeutic use</subject><subject>Antithyroid Agents - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Glutathione peroxidase</subject><subject>Glutathione Peroxidase - blood</subject><subject>Graves Disease - drug therapy</subject><subject>Graves' disease</subject><subject>Hemoglobins - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Methimazole - therapeutic use</subject><subject>Selenium</subject><subject>Selenium - blood</subject><subject>Spectrophotometry, Atomic</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNp9kctuFDEQRS0URCYJP8ACeZWsevCjX1bYRBEJSJFYQNaWx65mPOp2d2z3kPwGX0x1ZiR2rMou3zol30vIB87WnPH6025trQ1rwZjExpqJ9g1Z8baRhSyVOCErxpgqWtXyU3KW0g6vJav5O3LKS1U3vFIr8ufHPE09DBCyyX4M9LfPW2oCnp-9w5qoDzRvgeYIJi86Onb0Ppo9pCvqfAKT4PpVAV0HFp8D_dXPiNsiD-gE8RWVgBqb_d7nF-Q7asdgkRYPa5GZoIfg5-GCvO1Mn-D9sZ6Tx7svP2-_Fg_f77_d3jwUVlYiF7KxlZDAOUhRO-jKeuPA2qqVFeMlKKWa1mwsr0sOdb0pOwmuaZQwFTeiayp5Ti4P3CmOTzOkrAefLPS9CTDOSbcMHRJSolAchDaOKUXo9BT9YOKL5kwvSeidXpLQSxJLD5PAoY9H-rwZwP0bOVqPgs8HAeAf9x6iTtYDeuJ8RBu1G_3_-H8BBradpA</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Vrca, Vesna Bacic</creator><creator>Skreb, Franjo</creator><creator>Cepelak, Ivana</creator><creator>Romic, Zeljko</creator><creator>Mayer, Ljiljana</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and concentration of selenium</title><author>Vrca, Vesna Bacic ; Skreb, Franjo ; Cepelak, Ivana ; Romic, Zeljko ; Mayer, Ljiljana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-37c523e11e326def46bdecc5835014e99978abc1641e66b4f3ed7792a51a2f753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - therapeutic use</topic><topic>Antithyroid Agents - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Glutathione peroxidase</topic><topic>Glutathione Peroxidase - blood</topic><topic>Graves Disease - drug therapy</topic><topic>Graves' disease</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Methimazole - therapeutic use</topic><topic>Selenium</topic><topic>Selenium - blood</topic><topic>Spectrophotometry, Atomic</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vrca, Vesna Bacic</creatorcontrib><creatorcontrib>Skreb, Franjo</creatorcontrib><creatorcontrib>Cepelak, Ivana</creatorcontrib><creatorcontrib>Romic, Zeljko</creatorcontrib><creatorcontrib>Mayer, Ljiljana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vrca, Vesna Bacic</au><au>Skreb, Franjo</au><au>Cepelak, Ivana</au><au>Romic, Zeljko</au><au>Mayer, Ljiljana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and concentration of selenium</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>341</volume><issue>1</issue><spage>55</spage><epage>63</epage><pages>55-63</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Background: The effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) was monitored on the speed of attaining euthyroidism in a group of patients with Graves' disease, treated with methimazole.
Methods: The activity of glutathione peroxidase in whole blood and the concentrations of selenium, pituitary and thyroid hormones in serum were measured, prior to commencement of therapy and after 30 and 60 days.
Results: Patients who received supplementation with antioxidants in addition to therapy with methimazole (Group A,
n=29) attained euthyroidism faster than the patients treated with only methimazole (Group B,
n=28). The concentration of selenium in the serum of patients in Group A increased significantly during treatment (
p<0.001), while there was no statistically significant change in the patients in Group B. The concentration of selenium in the serum between the groups differed statistically significantly 30 days (
p<0.05) and 60 days (
p<0.01) after the commencement of therapy. Activity of glutathione peroxidase in whole blood increased during treatment in both groups of patients. However, a statistically more significant increase occurred in Group A compared to Group B, 30 days after the commencement of therapy (
p<0.01).
Conclusion: The results of the study clearly indicate that supplementation with antioxidants in the treatment of Graves' disease is justified, particularly those containing selenium.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>14967159</pmid><doi>10.1016/j.cccn.2003.10.028</doi><tpages>9</tpages></addata></record> |
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| ispartof | Clinica chimica acta, 2004-03, Vol.341 (1), p.55-63 |
| issn | 0009-8981 1873-3492 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Adult Antioxidants Antioxidants - metabolism Antioxidants - therapeutic use Antithyroid Agents - therapeutic use Drug Therapy, Combination Female Glutathione peroxidase Glutathione Peroxidase - blood Graves Disease - drug therapy Graves' disease Hemoglobins - metabolism Humans Male Methimazole - therapeutic use Selenium Selenium - blood Spectrophotometry, Atomic Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood |
| title | Supplementation with antioxidants in the treatment of Graves' disease; the effect on glutathione peroxidase activity and concentration of selenium |
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