The human corticosteroid binding globulin gene is located on chromosome 14q31-q32.1 near two other serine protease inhibitor genes

Human corticosteroid binding globulin (CBG) cDNA fragments were radiolabeled and hybridized in situ to metaphase chromosome preparations. The results localized the CBG gene to the q31-q32.1 region of human chromosome 14. This location also contains the genes for two closely related serine protease i...

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Bibliographic Details
Published in:Human genetics 1990-11, Vol.86 (1), p.73-75
Main Authors: SERALINI, G.-E, BERUBE, D, GAGNE, R, HAMMOND, G. L
Format: Article
Language:English
Subjects:
alpha 1-Antichymotrypsin - genetics
alpha 1-Antitrypsin - genetics
Biological and medical sciences
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 14
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Human
Humans
Karyotyping
Transcortin - genetics
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Summary:Human corticosteroid binding globulin (CBG) cDNA fragments were radiolabeled and hybridized in situ to metaphase chromosome preparations. The results localized the CBG gene to the q31-q32.1 region of human chromosome 14. This location also contains the genes for two closely related serine protease inhibitors: alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin. It is therefore likely that these genes evolved by duplication events, and it would appear that this region contains a series of functionally related genes.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00205177