ski can cause selective growth of skeletal muscle in transgenic mice

We have created several lines of mice that contain a truncated chicken c-ski cDNA linked to an MSV LTR promoter. Adult mice from three independent lines show large increases in skeletal muscle. All three lines of mice express high levels of c-ski mRNA and protein in skeletal muscle. All other tissue...

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Bibliographic Details
Published in:Genes & development 1990-09, Vol.4 (9), p.1462-1472
Main Authors: Sutrave, P, Kelly, A M, Hughes, S H
Format: Article
Language:English
Subjects:
Animals
Chickens
DNA-Binding Proteins - biosynthesis
DNA-Binding Proteins - genetics
DNA-Binding Proteins - physiology
Growth - genetics
Mice
Mice, Transgenic
Moloney murine sarcoma virus - genetics
Muscle Development
Proto-Oncogene Proteins - biosynthesis
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - physiology
Repetitive Sequences, Nucleic Acid - genetics
RNA, Messenger - analysis
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Summary:We have created several lines of mice that contain a truncated chicken c-ski cDNA linked to an MSV LTR promoter. Adult mice from three independent lines show large increases in skeletal muscle. All three lines of mice express high levels of c-ski mRNA and protein in skeletal muscle. All other tissues examined show little or no expression of the c-ski transgene. The muscles of one of the three lines were examined in more detail. Type II fast fibers undergo selective hypertrophy in affected muscles of this line.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.4.9.1462