Variation of benzbromarone elimination in man : a population study

The plasma benzbromarone concentration-time profile in a healthy subject who retained the compound much longer than other individuals is described. The data suggested that determination of the 24 h plasma concentration of the parent drug after a single oral dose of 100 mg benzbromarone would be an a...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1990-01, Vol.39 (2), p.173-176
Main Authors: WALTER-SACK, I, GRESSER, U, ADJAN, M, KAMILLI, I, ITTENSOHN, A, DE VRIES, J. X, WEBER, E, ZOÊLLNER, N
Format: Article
Language:English
Subjects:
Adult
Benzbromarone - pharmacokinetics
Biological and medical sciences
Female
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Phenotype
Urinary system
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Summary:The plasma benzbromarone concentration-time profile in a healthy subject who retained the compound much longer than other individuals is described. The data suggested that determination of the 24 h plasma concentration of the parent drug after a single oral dose of 100 mg benzbromarone would be an appropriate procedure to determine the elimination phenotype. Based on this procedure, 148 of 153 healthy individuals (97%) in a population study were found to eliminate benzbromarone rapidly. In one subject the 24 h benzbromarone plasma concentration was very similar to that observed in the individual who had been more fully characterized. Four participants gave intermediate results. The data are compatible with a bimodal or trimodal distribution of different benzbromarone elimination phenotypes.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00280054