Paracetamol test : modification by renal function, urine flow and pH

Factors which might affect paracetamol disposition have been studied in a heterogenous group of patients in need of mild analgesia in an intensive care unit. Following oral administration of 1 g of paracetamol, plasma and urinary concentrations of the parent compound and metabolites were assessed by...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1990-01, Vol.39 (3), p.245-251
Main Authors: KIETZMANN, D, BOCK, K. W, KRÄHMER, B, KETTLER, D, BIRCHER, J
Format: Article
Language:English
Subjects:
Acetaminophen - blood
Acetaminophen - pharmacokinetics
Acetaminophen - urine
Administration, Oral
Adult
Aged
Analgesics
Biological and medical sciences
Chromatography, High Pressure Liquid
Creatinine - metabolism
Female
Humans
Hydrogen-Ion Concentration
Kidney - drug effects
Kidney - metabolism
Male
Medical sciences
Metabolic Clearance Rate
Middle Aged
Neuropharmacology
Pharmacology. Drug treatments
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Summary:Factors which might affect paracetamol disposition have been studied in a heterogenous group of patients in need of mild analgesia in an intensive care unit. Following oral administration of 1 g of paracetamol, plasma and urinary concentrations of the parent compound and metabolites were assessed by HPLC. The renal clearance of paracetamol was significantly correlated with urine flow (r = 0.84) and creatinine clearance (r = 0.77), but not with urine pH. Metabolite output was diminished in patients with reduced renal function. Despite the heterogeneity of patients and the diversity of drug treatment, the urine to plasma paracetamol concentration ratio appeared remarkably constant in patients with normal renal function (9.8 +/- 2.7). It is concluded that the metabolite to paracetamol ratio may only be regarded as a measure of the drug metabolizing capacity in subjects with normal renal function, if factors influencing urine volume and paracetamol absorption are standardized.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00315104