Anti-HLA antibodies in heart transplantation

We have analyzed the relationship between the development of transplant-related coronary artery disease (TRCAD) and the following potential risk factors: (a) number of HLA mismatches between recipient and donor; (b) production of anti-HLA antibodies; (c) growth of lymphocytes infiltrating the graft;...

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Bibliographic Details
Published in:Transplant immunology 2004, Vol.12 (2), p.177-183
Main Authors: Vasilescu, Elena R, Ho, Eric K, Torre, Ludwika de la, Itescu, Silviu, Marboe, Charles, Cortesini, Raffaello, Suciu-Foca, Nicole, Mancini, Donna
Format: Article
Language:English
Subjects:
Antibodies - immunology
Coronary Artery Disease - immunology
Female
Follow-Up Studies
Graft Rejection - immunology
Graft Rejection - pathology
Graft Survival - immunology
Heart transplantation
Heart Transplantation - immunology
HLA antibodies
HLA Antigens - immunology
Humans
Male
Middle Aged
Probability
Risk Factors
Transplant-related coronary artery disease
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Summary:We have analyzed the relationship between the development of transplant-related coronary artery disease (TRCAD) and the following potential risk factors: (a) number of HLA mismatches between recipient and donor; (b) production of anti-HLA antibodies; (c) growth of lymphocytes infiltrating the graft; and (d) frequency of biopsy proven episodes of acute rejection. The study population consisted of 285 adult heart allograft recipients who were monitored over a period of two years or more. The results demonstrate a significant correlation between TRCAD, generation of anti-HLA class II antibodies and potential of lymphocytes infiltrating the graft to proliferate ex-vivo in medium containing IL-2. Humoral and cellular immune responses to HLA-DR antigens expressed by the graft seem to underlie the development of TRCAD.
ISSN:0966-3274
1878-5492
DOI:10.1016/j.trim.2003.08.002