Incidence of the WAIS-R Fuld profile in HIV-1 infection

The incidence of a WAIS-R subtest "marker" sensitive to cholinergic dysfunction was assessed in a sample 116 homosexual males infected with HIV (Acquired Immunodeficiency Syndrome [AIDS] N = 40; AIDS Related Complex [ARC], N = 76). The incidence of positive profiles was low in the overall...

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Bibliographic Details
Published in:Journal of clinical and experimental neuropsychology 1990-10, Vol.12 (5), p.807-811
Main Authors: van Gorp, W G, Tulin, S J, Evans, G, Satz, P
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - physiopathology
Acquired Immunodeficiency Syndrome - psychology
Adult
AIDS Dementia Complex - physiopathology
AIDS Dementia Complex - psychology
AIDS-Related Complex - physiopathology
AIDS-Related Complex - psychology
AIDS/HIV
Brain - physiopathology
Cholinergic Fibers - physiology
HIV Infections - physiopathology
HIV Infections - psychology
HIV-1 - pathogenicity
Homosexuality - psychology
Humans
Middle Aged
Psychometrics
Receptors, Cholinergic - physiology
Wechsler Scales
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Summary:The incidence of a WAIS-R subtest "marker" sensitive to cholinergic dysfunction was assessed in a sample 116 homosexual males infected with HIV (Acquired Immunodeficiency Syndrome [AIDS] N = 40; AIDS Related Complex [ARC], N = 76). The incidence of positive profiles was low in the overall sample (11/116, 9%), and significantly lower than incidence rates reported for known cholinergic deficient groups (Alzheimer's disease; scopolamine). However, significantly more AIDS patients (8/40, 20%) than ARC patients (3/76, 4%) demonstrated positive profiles. These results suggest that, as a group, persons with ARC or AIDS do not show an increased incidence of the Fuld profile associated with cholinergic disruption, and offer continued support for diagnostic specificity of the Fuld formula for Alzheimer's disease.
ISSN:1380-3395
DOI:10.1080/01688639008401021