Comparison of coronary artery specific leukocyte–platelet conjugate formation in unstable versus stable angina pectoris

This study evaluates transcoronary changes in neutrophil and platelet activation and conjugate formation in patients with angina pectoris secondary to coronary artery disease. We examined parameters of neutrophil and platelet activation as well as the neutrophil–platelet conjugate formation in patie...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2004-02, Vol.93 (4), p.410-413
Main Authors: Patel, Parag B, Pfau, Steven E, Cleman, Michael W, Brennan, Joseph J, Howes, Christopher, Remetz, Michael, Cabin, Henry S, Setaro, John F, Rinder, Henry M
Format: Article
Language:English
Subjects:
Angina pectoris
Angina Pectoris - blood
Angina Pectoris - diagnostic imaging
Angina Pectoris - immunology
Angina, Unstable - blood
Angina, Unstable - diagnostic imaging
Angina, Unstable - immunology
Antibodies, Monoclonal
Biological and medical sciences
C-Reactive Protein - metabolism
Cardiology. Vascular system
Chi-Square Distribution
Comparative analysis
Coronary Angiography
Coronary Disease - complications
Coronary heart disease
Coronary vessels
Female
Flow Cytometry
Heart
Humans
Leukocytes
Male
Medical research
Medical sciences
Middle Aged
Neutrophil Activation
Platelet Activation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study evaluates transcoronary changes in neutrophil and platelet activation and conjugate formation in patients with angina pectoris secondary to coronary artery disease. We examined parameters of neutrophil and platelet activation as well as the neutrophil–platelet conjugate formation in patients who underwent diagnostic coronary angiography. Thirty-nine patients with chest pain referred for cardiac catheterization were studied (23 patients with unstable angina pectoris [UAP] and 16 with stable angina pectoris [SAP]). Before coronary angiography, blood samples were obtained simultaneously from the aortic root and coronary sinus to assess leukocyte (CD11b) and platelet (CD62P) activation and leukocyte–platelet conjugates. There was a 94% increase in CD62-expressing platelets from the aorta to the coronary sinus in patients with UAP compared with a 49% increase in patients with SAP. The percentage of neutrophil–platelet conjugates increased by 22% in patients with UAP compared with a 16% decrease in those with SAP (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2003.10.033