Loading…
Comparison of coronary artery specific leukocyte–platelet conjugate formation in unstable versus stable angina pectoris
This study evaluates transcoronary changes in neutrophil and platelet activation and conjugate formation in patients with angina pectoris secondary to coronary artery disease. We examined parameters of neutrophil and platelet activation as well as the neutrophil–platelet conjugate formation in patie...
Saved in:
| Published in: | The American journal of cardiology 2004-02, Vol.93 (4), p.410-413 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c484t-6105e29c8b805159fcda0722f2453bb3cee8495a66fa6887e0618b53c75df1103 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c484t-6105e29c8b805159fcda0722f2453bb3cee8495a66fa6887e0618b53c75df1103 |
| container_end_page | 413 |
| container_issue | 4 |
| container_start_page | 410 |
| container_title | The American journal of cardiology |
| container_volume | 93 |
| creator | Patel, Parag B Pfau, Steven E Cleman, Michael W Brennan, Joseph J Howes, Christopher Remetz, Michael Cabin, Henry S Setaro, John F Rinder, Henry M |
| description | This study evaluates transcoronary changes in neutrophil and platelet activation and conjugate formation in patients with angina pectoris secondary to coronary artery disease. We examined parameters of neutrophil and platelet activation as well as the neutrophil–platelet conjugate formation in patients who underwent diagnostic coronary angiography. Thirty-nine patients with chest pain referred for cardiac catheterization were studied (23 patients with unstable angina pectoris [UAP] and 16 with stable angina pectoris [SAP]). Before coronary angiography, blood samples were obtained simultaneously from the aortic root and coronary sinus to assess leukocyte (CD11b) and platelet (CD62P) activation and leukocyte–platelet conjugates. There was a 94% increase in CD62-expressing platelets from the aorta to the coronary sinus in patients with UAP compared with a 49% increase in patients with SAP. The percentage of neutrophil–platelet conjugates increased by 22% in patients with UAP compared with a 16% decrease in those with SAP (p |
| doi_str_mv | 10.1016/j.amjcard.2003.10.033 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80170297</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002914903015704</els_id><sourcerecordid>80170297</sourcerecordid><originalsourceid>FETCH-LOGICAL-c484t-6105e29c8b805159fcda0722f2453bb3cee8495a66fa6887e0618b53c75df1103</originalsourceid><addsrcrecordid>eNqFkd-K1TAQxoMo7nH1EZQi6F2P-dOk6ZUsB__Bgjd6HdJ0sqS2SU3ShXPnO_iGPokpp7DgjVfDDL_5Zvg-hF4SfCSYiHfjUc-j0XE4UoxZmR0xY4_Qgci2q0lH2GN0wBjTuiNNd4WepTSWlhAunqKrMhKdIPSAzqcwLzq6FHwVbGVCDF7Hc6VjhlLSAsZZZ6oJ1h_BnDP8-fV7mXSGCXKh_bjelaayIc46uyLifLX6lHU_QXUPMa2p2jvt75zXVVHMoRx8jp5YPSV4sddr9P3jh2-nz_Xt109fTje3tWlkk2tBMAfaGdlLzAnvrBk0bim1tOGs75kBkE3HtRBWCylbwILInjPT8sESgtk1envRXWL4uULKanbJwDRpD2FNSmLSYtq1BXz9DziGNfrym6IMM4Gp2NT4BTIxpBTBqiW6uTimCFZbMGpUezBqC2Ybl2DK3qtdfO1nGB629iQK8GYHdDJ6slF749IDx1tGJdu49xcOimf3DqJKxoE3MLhYnFVDcP955S8vGrE3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>230360260</pqid></control><display><type>article</type><title>Comparison of coronary artery specific leukocyte–platelet conjugate formation in unstable versus stable angina pectoris</title><source>Elsevier</source><creator>Patel, Parag B ; Pfau, Steven E ; Cleman, Michael W ; Brennan, Joseph J ; Howes, Christopher ; Remetz, Michael ; Cabin, Henry S ; Setaro, John F ; Rinder, Henry M</creator><creatorcontrib>Patel, Parag B ; Pfau, Steven E ; Cleman, Michael W ; Brennan, Joseph J ; Howes, Christopher ; Remetz, Michael ; Cabin, Henry S ; Setaro, John F ; Rinder, Henry M</creatorcontrib><description>This study evaluates transcoronary changes in neutrophil and platelet activation and conjugate formation in patients with angina pectoris secondary to coronary artery disease. We examined parameters of neutrophil and platelet activation as well as the neutrophil–platelet conjugate formation in patients who underwent diagnostic coronary angiography. Thirty-nine patients with chest pain referred for cardiac catheterization were studied (23 patients with unstable angina pectoris [UAP] and 16 with stable angina pectoris [SAP]). Before coronary angiography, blood samples were obtained simultaneously from the aortic root and coronary sinus to assess leukocyte (CD11b) and platelet (CD62P) activation and leukocyte–platelet conjugates. There was a 94% increase in CD62-expressing platelets from the aorta to the coronary sinus in patients with UAP compared with a 49% increase in patients with SAP. The percentage of neutrophil–platelet conjugates increased by 22% in patients with UAP compared with a 16% decrease in those with SAP (p <0.01). In contrast, monocyte-platelet binding across the coronary bed increased to a similar degree in both groups. This study demonstrates an increase in neutrophil–platelet conjugates across the coronary circulation in UAP, compatible with a higher activation state in both cell types.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2003.10.033</identifier><identifier>PMID: 14969612</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Angina pectoris ; Angina Pectoris - blood ; Angina Pectoris - diagnostic imaging ; Angina Pectoris - immunology ; Angina, Unstable - blood ; Angina, Unstable - diagnostic imaging ; Angina, Unstable - immunology ; Antibodies, Monoclonal ; Biological and medical sciences ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Chi-Square Distribution ; Comparative analysis ; Coronary Angiography ; Coronary Disease - complications ; Coronary heart disease ; Coronary vessels ; Female ; Flow Cytometry ; Heart ; Humans ; Leukocytes ; Male ; Medical research ; Medical sciences ; Middle Aged ; Neutrophil Activation ; Platelet Activation</subject><ispartof>The American journal of cardiology, 2004-02, Vol.93 (4), p.410-413</ispartof><rights>2004 Excerpta Medica Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Feb 15, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-6105e29c8b805159fcda0722f2453bb3cee8495a66fa6887e0618b53c75df1103</citedby><cites>FETCH-LOGICAL-c484t-6105e29c8b805159fcda0722f2453bb3cee8495a66fa6887e0618b53c75df1103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15732832$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14969612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Parag B</creatorcontrib><creatorcontrib>Pfau, Steven E</creatorcontrib><creatorcontrib>Cleman, Michael W</creatorcontrib><creatorcontrib>Brennan, Joseph J</creatorcontrib><creatorcontrib>Howes, Christopher</creatorcontrib><creatorcontrib>Remetz, Michael</creatorcontrib><creatorcontrib>Cabin, Henry S</creatorcontrib><creatorcontrib>Setaro, John F</creatorcontrib><creatorcontrib>Rinder, Henry M</creatorcontrib><title>Comparison of coronary artery specific leukocyte–platelet conjugate formation in unstable versus stable angina pectoris</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>This study evaluates transcoronary changes in neutrophil and platelet activation and conjugate formation in patients with angina pectoris secondary to coronary artery disease. We examined parameters of neutrophil and platelet activation as well as the neutrophil–platelet conjugate formation in patients who underwent diagnostic coronary angiography. Thirty-nine patients with chest pain referred for cardiac catheterization were studied (23 patients with unstable angina pectoris [UAP] and 16 with stable angina pectoris [SAP]). Before coronary angiography, blood samples were obtained simultaneously from the aortic root and coronary sinus to assess leukocyte (CD11b) and platelet (CD62P) activation and leukocyte–platelet conjugates. There was a 94% increase in CD62-expressing platelets from the aorta to the coronary sinus in patients with UAP compared with a 49% increase in patients with SAP. The percentage of neutrophil–platelet conjugates increased by 22% in patients with UAP compared with a 16% decrease in those with SAP (p <0.01). In contrast, monocyte-platelet binding across the coronary bed increased to a similar degree in both groups. This study demonstrates an increase in neutrophil–platelet conjugates across the coronary circulation in UAP, compatible with a higher activation state in both cell types.</description><subject>Angina pectoris</subject><subject>Angina Pectoris - blood</subject><subject>Angina Pectoris - diagnostic imaging</subject><subject>Angina Pectoris - immunology</subject><subject>Angina, Unstable - blood</subject><subject>Angina, Unstable - diagnostic imaging</subject><subject>Angina, Unstable - immunology</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Chi-Square Distribution</subject><subject>Comparative analysis</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - complications</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Heart</subject><subject>Humans</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neutrophil Activation</subject><subject>Platelet Activation</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNqFkd-K1TAQxoMo7nH1EZQi6F2P-dOk6ZUsB__Bgjd6HdJ0sqS2SU3ShXPnO_iGPokpp7DgjVfDDL_5Zvg-hF4SfCSYiHfjUc-j0XE4UoxZmR0xY4_Qgci2q0lH2GN0wBjTuiNNd4WepTSWlhAunqKrMhKdIPSAzqcwLzq6FHwVbGVCDF7Hc6VjhlLSAsZZZ6oJ1h_BnDP8-fV7mXSGCXKh_bjelaayIc46uyLifLX6lHU_QXUPMa2p2jvt75zXVVHMoRx8jp5YPSV4sddr9P3jh2-nz_Xt109fTje3tWlkk2tBMAfaGdlLzAnvrBk0bim1tOGs75kBkE3HtRBWCylbwILInjPT8sESgtk1envRXWL4uULKanbJwDRpD2FNSmLSYtq1BXz9DziGNfrym6IMM4Gp2NT4BTIxpBTBqiW6uTimCFZbMGpUezBqC2Ybl2DK3qtdfO1nGB629iQK8GYHdDJ6slF749IDx1tGJdu49xcOimf3DqJKxoE3MLhYnFVDcP955S8vGrE3</recordid><startdate>20040215</startdate><enddate>20040215</enddate><creator>Patel, Parag B</creator><creator>Pfau, Steven E</creator><creator>Cleman, Michael W</creator><creator>Brennan, Joseph J</creator><creator>Howes, Christopher</creator><creator>Remetz, Michael</creator><creator>Cabin, Henry S</creator><creator>Setaro, John F</creator><creator>Rinder, Henry M</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040215</creationdate><title>Comparison of coronary artery specific leukocyte–platelet conjugate formation in unstable versus stable angina pectoris</title><author>Patel, Parag B ; Pfau, Steven E ; Cleman, Michael W ; Brennan, Joseph J ; Howes, Christopher ; Remetz, Michael ; Cabin, Henry S ; Setaro, John F ; Rinder, Henry M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-6105e29c8b805159fcda0722f2453bb3cee8495a66fa6887e0618b53c75df1103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Angina pectoris</topic><topic>Angina Pectoris - blood</topic><topic>Angina Pectoris - diagnostic imaging</topic><topic>Angina Pectoris - immunology</topic><topic>Angina, Unstable - blood</topic><topic>Angina, Unstable - diagnostic imaging</topic><topic>Angina, Unstable - immunology</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Chi-Square Distribution</topic><topic>Comparative analysis</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - complications</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Heart</topic><topic>Humans</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neutrophil Activation</topic><topic>Platelet Activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Parag B</creatorcontrib><creatorcontrib>Pfau, Steven E</creatorcontrib><creatorcontrib>Cleman, Michael W</creatorcontrib><creatorcontrib>Brennan, Joseph J</creatorcontrib><creatorcontrib>Howes, Christopher</creatorcontrib><creatorcontrib>Remetz, Michael</creatorcontrib><creatorcontrib>Cabin, Henry S</creatorcontrib><creatorcontrib>Setaro, John F</creatorcontrib><creatorcontrib>Rinder, Henry M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Parag B</au><au>Pfau, Steven E</au><au>Cleman, Michael W</au><au>Brennan, Joseph J</au><au>Howes, Christopher</au><au>Remetz, Michael</au><au>Cabin, Henry S</au><au>Setaro, John F</au><au>Rinder, Henry M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of coronary artery specific leukocyte–platelet conjugate formation in unstable versus stable angina pectoris</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2004-02-15</date><risdate>2004</risdate><volume>93</volume><issue>4</issue><spage>410</spage><epage>413</epage><pages>410-413</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>This study evaluates transcoronary changes in neutrophil and platelet activation and conjugate formation in patients with angina pectoris secondary to coronary artery disease. We examined parameters of neutrophil and platelet activation as well as the neutrophil–platelet conjugate formation in patients who underwent diagnostic coronary angiography. Thirty-nine patients with chest pain referred for cardiac catheterization were studied (23 patients with unstable angina pectoris [UAP] and 16 with stable angina pectoris [SAP]). Before coronary angiography, blood samples were obtained simultaneously from the aortic root and coronary sinus to assess leukocyte (CD11b) and platelet (CD62P) activation and leukocyte–platelet conjugates. There was a 94% increase in CD62-expressing platelets from the aorta to the coronary sinus in patients with UAP compared with a 49% increase in patients with SAP. The percentage of neutrophil–platelet conjugates increased by 22% in patients with UAP compared with a 16% decrease in those with SAP (p <0.01). In contrast, monocyte-platelet binding across the coronary bed increased to a similar degree in both groups. This study demonstrates an increase in neutrophil–platelet conjugates across the coronary circulation in UAP, compatible with a higher activation state in both cell types.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>14969612</pmid><doi>10.1016/j.amjcard.2003.10.033</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 2004-02, Vol.93 (4), p.410-413 |
| issn | 0002-9149 1879-1913 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80170297 |
| source | Elsevier |
| subjects | Angina pectoris Angina Pectoris - blood Angina Pectoris - diagnostic imaging Angina Pectoris - immunology Angina, Unstable - blood Angina, Unstable - diagnostic imaging Angina, Unstable - immunology Antibodies, Monoclonal Biological and medical sciences C-Reactive Protein - metabolism Cardiology. Vascular system Chi-Square Distribution Comparative analysis Coronary Angiography Coronary Disease - complications Coronary heart disease Coronary vessels Female Flow Cytometry Heart Humans Leukocytes Male Medical research Medical sciences Middle Aged Neutrophil Activation Platelet Activation |
| title | Comparison of coronary artery specific leukocyte–platelet conjugate formation in unstable versus stable angina pectoris |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T15%3A27%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparison%20of%20coronary%20artery%20specific%20leukocyte%E2%80%93platelet%20conjugate%20formation%20in%20unstable%20versus%20stable%20angina%20pectoris&rft.jtitle=The%20American%20journal%20of%20cardiology&rft.au=Patel,%20Parag%20B&rft.date=2004-02-15&rft.volume=93&rft.issue=4&rft.spage=410&rft.epage=413&rft.pages=410-413&rft.issn=0002-9149&rft.eissn=1879-1913&rft.coden=AJCDAG&rft_id=info:doi/10.1016/j.amjcard.2003.10.033&rft_dat=%3Cproquest_cross%3E80170297%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c484t-6105e29c8b805159fcda0722f2453bb3cee8495a66fa6887e0618b53c75df1103%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=230360260&rft_id=info:pmid/14969612&rfr_iscdi=true |